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. 2023 Sep;27(3):399-409.
doi: 10.1007/s10006-022-01084-9. Epub 2022 Jun 4.

Prevalence of dental alterations in patients under bisphosphonates therapy: a systematic review

Monique Abreu Pauli  1 , Natália Cristina Trentin Bordignon  2 , Geórgia Ribeiro Martini  2 , Mariana Comparotto Minamisako  3 , Rogério Gondak  4
Affiliations

Prevalence of dental alterations in patients under bisphosphonates therapy: a systematic review

Monique Abreu Pauli et al. Oral Maxillofac Surg. 2023 Sep.

Abstract

This systematic review aimed to estimate the prevalence and describe dentoalveolar lesions associated with bisphosphonates therapy. A systematic review of the literature was conducted using the following databases: PubMed, Embase, Cochrane, CINAHL, Scopus, Web of Science, Lilacs, SciElo, and Grey Literature. Quality of individual studies analysis was performed by using Newcastle-Ottawa Scale. Certainty of cumulative evidence was achieved by applying Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria. The software R Statistics version 4.0.5 (The R Foundation) was used for proportion estimations per study and corresponding confidence intervals were estimated through the Clopper-Pearson method. Four articles were included for the qualitative synthesis. Two studies were considered of good quality, one of fair, and one of poor quality. A total of 231 patients were encompassed. Widening of the periodontal ligament space (22.2-39.7%), periradicular radiolucencies (20-22.9%), and pulp calcifications (33.3-69.2%) were the most frequent alterations. Certainty of evidence was rated as very low. Based on limited evidence, this systematic review reports a variety of dentoalveolar alterations in patients under bisphosphonate therapy. These features might impact on dental clinical practice. However, the level of evidence is considered very low due to important limitations.

Keywords: Bisphosphonates; Evidence-based dentistry; Systematic review; Teeth.

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