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. 1978 Sep;92(3):681-90.

Lymphoid thyroiditis following immunization with group A streptococcal vaccine

N Tonooka, G A Leslie, M A Greer, J C Olson

Lymphoid thyroiditis following immunization with group A streptococcal vaccine

N Tonooka et al. Am J Pathol. 1978 Sep.

Abstract

Severe lymphoid thyroiditis and associated hypothyroidism occurred in all of 7 male and 4 female F(7) derivatives (seventh generation) of rats immunized in each generation against Group A streptococci. This evidence of thyroiditis produced by immunization against a nonthyroidal antigen suggests that some cases of Hashimoto's thyroiditis in humans may result from nonspecific immune responses.

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References

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