Targeting CD47/SIRPα in Acute Myeloid Leukemia and Myelodysplastic Syndrome: Preclinical and Clinical Developments of Magrolimab
- PMID: 35663535
- PMCID: PMC9153253
- DOI: 10.36401/JIPO-21-X2
Targeting CD47/SIRPα in Acute Myeloid Leukemia and Myelodysplastic Syndrome: Preclinical and Clinical Developments of Magrolimab
Keywords: AML; CD47; MDS; azacitidine; magrolimab.
Conflict of interest statement
Conflict of Interest: Naval Daver reports research funding from Daiichi Sankyo, Bristol-Myers Squibb, Pfizer, Karyopharm, Sevier, Genentech, Astellas, Abbvie, Genentech, Novimmune, Amgen, Trovagene, Gilead, FATE therapeutics, Trillium, Hanmi, Newave, Glycomimetics, and ImmunoGen. He has served in a consulting or advisory role for Daiichi Sankyo, Bristol-Myers Squibb, Pfizer, Novartis, Celgene, AbbVie, Genentech, Servier, Trillium, Syndax, Trovagene, Astellas, Gilead, STAR therapeutics, KITE, and Agios. Fadi Haddad has nothing to disclose.
References
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- Okazawa H, Motegi S, Ohyama N, et al. Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system. J Immunol . 2005;174:2004–2011. - PubMed
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