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. 2021 May 14;4(2):67-71.
doi: 10.36401/JIPO-21-X2. eCollection 2021 May.

Targeting CD47/SIRPα in Acute Myeloid Leukemia and Myelodysplastic Syndrome: Preclinical and Clinical Developments of Magrolimab

Affiliations

Targeting CD47/SIRPα in Acute Myeloid Leukemia and Myelodysplastic Syndrome: Preclinical and Clinical Developments of Magrolimab

Fadi Haddad et al. J Immunother Precis Oncol. .
No abstract available

Keywords: AML; CD47; MDS; azacitidine; magrolimab.

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Conflict of interest statement

Conflict of Interest: Naval Daver reports research funding from Daiichi Sankyo, Bristol-Myers Squibb, Pfizer, Karyopharm, Sevier, Genentech, Astellas, Abbvie, Genentech, Novimmune, Amgen, Trovagene, Gilead, FATE therapeutics, Trillium, Hanmi, Newave, Glycomimetics, and ImmunoGen. He has served in a consulting or advisory role for Daiichi Sankyo, Bristol-Myers Squibb, Pfizer, Novartis, Celgene, AbbVie, Genentech, Servier, Trillium, Syndax, Trovagene, Astellas, Gilead, STAR therapeutics, KITE, and Agios. Fadi Haddad has nothing to disclose.

References

    1. Brown EJ, Frazier WA. Integrin-associated protein (CD47) and its ligands. Trends Cell Biol . 2001;11:130–135. - PubMed
    1. Barclay AN, Brown MH. The SIRP family of receptors and immune regulation. Nat Rev Immunol . 2006;6:457–464. - PubMed
    1. Okazawa H, Motegi S, Ohyama N, et al. Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system. J Immunol . 2005;174:2004–2011. - PubMed
    1. Chao MP, Weissman IL, Majeti R. The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications. Curr Opin Immunol . 2012;24:225–232. - PMC - PubMed
    1. Majeti R, Chao MP, Alizadeh AA, et al. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell . 2009;138:286–299. - PMC - PubMed

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