Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022;17(2):152-161.
doi: 10.5114/pg.2021.108453. Epub 2021 Aug 13.

Comparison of one anastomosis gastric bypass versus standard Roux-en-Y gastric bypass versus a variant of biliopancreatic diversion, in a case-matched, non-superobese population: 6 years of follow-up

George Markopoulos  1 , George Skroubis  1 , Fotis Kalfarentzos  1 , Ioannis Kehagias  1
Affiliations

Comparison of one anastomosis gastric bypass versus standard Roux-en-Y gastric bypass versus a variant of biliopancreatic diversion, in a case-matched, non-superobese population: 6 years of follow-up

George Markopoulos et al. Prz Gastroenterol. 2022.

Abstract

Introduction: One anastomosis gastric bypass (OAGB) is gaining increasing acceptance as a simple, safe, and effective operation for treating morbid obesity. Data comparing this procedure with the most effective biliopancreatic diversions (BPD) remain scarce, and most studies evaluate OAGB against standard Roux-en-Y gastric bypass (RYGB).

Aim: To present the mid-term results of a comparison of RYGB, OAGB, and our modification of BPD in an exclusively non-superobese population, regarding safety, efficacy, preservation of weight loss, as well as late postoperative metabolic and non-metabolic complications.

Material and methods: From our cohorts of patients treated for morbid obesity with OAGB, RYGB, and BPD at Patras University Hospital, we identified patients who had case-matched preoperative profiles regarding age, preoperative body mass index (BMI), and obesity-related comorbidities (diabetes mellitus, hypertension, and dyslipidaemia). Thirty-four patients from each group were included in the study. Bariatric outcomes, non-metabolic complications, and postoperative metabolic parameters were followed until the 6th postoperative year.

Results: The average patient age was 37.4 years (range: 19-57), 85.3% were female and 14.7% were male, with a mean BMI of 46.3 kg/m2 (range: 38.3-49.7). Regarding weight loss and glycaemic control, OAGB had comparable results to BPD and was significantly better than RYGB. The safety profile was analogous to RYGB, with the exception of calcium levels, which, even though they were within normal range, were significantly lower than those in RYGB. Comorbidities were successfully treated with all operations at comparable rates. In this cohort, no other major complications were observed.

Conclusions: OAGB offered mid-term results comparable to BPD while being safe and with minimal impact on the patient's nutritional state. It is an effective procedure for treating morbid obesity, which results in sustained weight loss and a high rate of resolution of comorbidities.

Keywords: biliopancreatic diversion; gastric bypass; metabolic deficiencies.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Follow-up rates during the study
Figure 2
Figure 2
Ca++ and PTH levels
Figure 3
Figure 3
Secondary hyperparathyroidism
Figure 4
Figure 4
Haemoglobin levels and anaemia (Hb < 12 g/dl) prevalence in women
Figure 5
Figure 5
Efficacy of the procedures
Figure 6
Figure 6
Resolution of comorbidities. Number of patients being treated for diabetes, dyslipidaemia, and hypertension
Figure 7
Figure 7
Glycaemic control of diabetic patients. HbA1c for patients with preoperative DM
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Maggard MA, Shugarman LR, Suttorp M, et al. . Metaanalysis: surgical treatment of obesity. Ann Intern Med 2005; 142: 547-59. - PubMed
    1. Buchwald H. Overview of bariatric surgery. J Am Coll Surg 2002; 194: 367-75. - PubMed
    1. Pournaras DJ, Aasheim ET, Bueter M, et al. . Effect of bypassing the proximal gut hormones involved with glycemic control and weight loss. Surg Obes Relat Dis 2012; 8: 371-4. - PubMed
    1. Chronaiou A, Tsoli M, Kehagias I, et al. . Lower ghrelin levels and exaggerated postprandial peptide-YY, glucagon-like peptide-1 and insulin responses, after gastric fundus resection, in patients undergoing Roux-en-Y gastric bypass: a randomized clinical trial. Obes Surg 2012; 22: 1761-70. - PubMed
    1. Rutledge R, Walsh TR. Continued excellent results with the minigastric bypass: six-year study in 2,410 patients. Obes Surg 2005; 15: 1304-8. - PubMed