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Case Reports
. 2022 Apr 30;14(4):e24627.
doi: 10.7759/cureus.24627. eCollection 2022 Apr.

A Persistent Parvovirus Infection Causing Anemia in an HIV Patient Requiring Intravenous Immunoglobulin Maintenance Therapy

Dhairya Gor  1 , Vinit Singh  2 , Varsha Gupta  3 , Michael Levitt  3
Affiliations
Case Reports

A Persistent Parvovirus Infection Causing Anemia in an HIV Patient Requiring Intravenous Immunoglobulin Maintenance Therapy

Dhairya Gor et al. Cureus. .

Abstract

Anemia is a common finding in a human immunodeficiency virus (HIV)-positive patient with a wide range of possible causes and is a significant risk factor for mortality in acquired immunodeficiency syndrome (AIDS). Opportunistic parvovirus infection-causing pure red cell aplasia is one of its uncommon causes. It has been suggested that immunocompromised patients with abnormal antibody production are more susceptible to acquiring a chronic parvovirus infection requiring long-term intravenous immunoglobulin (IVIg) treatment; however, there are no specific guidelines for it. Here, we present a case of an HIV patient with persistent parvovirus infection resulting in chronic anemia requiring long-term maintenance immunoglobulin therapy with an excellent therapeutic response.

Keywords: anemia; hematology; hiv; intravenous immunoglobulins; parvovirus b19.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Graph showing the trend in hemoglobin levels, HIV RNA copies, and CD4 counts after treatment initiation
CD4: Cluster of differentiation 4; qPCR: quantitative polymerase chain reaction.
Figure 2
Figure 2. Graph showing the trend in hemoglobin levels and parvovirus DNA copies after treatment initiation
See this image and copyright information in PMC

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