Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Apr 30;14(4):e24627.
doi: 10.7759/cureus.24627. eCollection 2022 Apr.

A Persistent Parvovirus Infection Causing Anemia in an HIV Patient Requiring Intravenous Immunoglobulin Maintenance Therapy

Dhairya Gor  1 , Vinit Singh  2 , Varsha Gupta  3 , Michael Levitt  3
Affiliations
Case Reports

A Persistent Parvovirus Infection Causing Anemia in an HIV Patient Requiring Intravenous Immunoglobulin Maintenance Therapy

Dhairya Gor et al. Cureus. .

Abstract

Anemia is a common finding in a human immunodeficiency virus (HIV)-positive patient with a wide range of possible causes and is a significant risk factor for mortality in acquired immunodeficiency syndrome (AIDS). Opportunistic parvovirus infection-causing pure red cell aplasia is one of its uncommon causes. It has been suggested that immunocompromised patients with abnormal antibody production are more susceptible to acquiring a chronic parvovirus infection requiring long-term intravenous immunoglobulin (IVIg) treatment; however, there are no specific guidelines for it. Here, we present a case of an HIV patient with persistent parvovirus infection resulting in chronic anemia requiring long-term maintenance immunoglobulin therapy with an excellent therapeutic response.

Keywords: anemia; hematology; hiv; intravenous immunoglobulins; parvovirus b19.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Graph showing the trend in hemoglobin levels, HIV RNA copies, and CD4 counts after treatment initiation
CD4: Cluster of differentiation 4; qPCR: quantitative polymerase chain reaction.
Figure 2
Figure 2. Graph showing the trend in hemoglobin levels and parvovirus DNA copies after treatment initiation
See this image and copyright information in PMC

References

    1. Parvovirus B19. Young NS, Brown KE. https://doi.org/10.1056/NEJMra030840. N Engl J Med. 2004;350:586–597. - PubMed
    1. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 36-1993. A 28-year-old man with AIDS, persistent pancytopenia, and lymphoma. https://www.nejm.org/doi/10.1056/NEJM199309093291109. N Engl J Med. 1993;329:792–799. - PubMed
    1. Human parvovirus B19. Heegaard ED, Brown KE. Clin Microbiol Rev. 2002;15:485–505. - PMC - PubMed
    1. Chronic pure red cell aplasia caused by parvovirus B19 in AIDS: use of intravenous immunoglobulin--a report of eight patients. Koduri PR, Kumapley R, Valladares J, Teter C. Am J Hematol. 1999;61:16–20. - PubMed
    1. Clinical relevance of parvovirus B19 as a cause of anemia in patients with human immunodeficiency virus infection. Abkowitz JL, Brown KE, Wood RW, Kovach NL, Green SW, Young NS. https://doi.org/10.1086/517264. J Infect Dis. 1997;176:269–273. - PubMed

Publication types

LinkOut - more resources