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Review
. 2022 May 6;10(13):3969-3980.
doi: 10.12998/wjcc.v10.i13.3969.

COVID-19 and liver diseases, what we know so far

Mohamed Elnaggar  1 , Ahmed Abomhya  2 , Ismail Elkhattib  3 , Nabila Dawoud  4 , Rajkumar Doshi  5
Affiliations
Review

COVID-19 and liver diseases, what we know so far

Mohamed Elnaggar et al. World J Clin Cases. .

Abstract

Coronavirus disease 2019 (COVID-19) pneumonia outbreak started in December 2019. On March 12, 2020, the World Health Organization (WHO) declared that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) constitutes a pandemic, and as of May 2021, SARS-CoV-2 has infected over 167.3 million patients, including 3.4 million deaths, reported to WHO. In this review, we will focus on the relationship between SARS-CoV-2 infection and the liver. We will discuss how chronic liver diseases affect the COVID-19 disease course and outcomes. We will also discuss the SARS-CoV-2 effects on the liver, mechanisms of acute liver injury, and potential management plans.

Keywords: COIVD-19; Hepatocellular carcinoma; Liver diseases; Non alcoholic fatty liver; SARS-CoV-2; Transaminases.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1
Figure 1
Mechanisms of liver injury in coronavirus disease 2019. COVID-19: Coronavirus disease 2019; SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2.
See this image and copyright information in PMC

References

    1. WHO WHO Coronavirus (COVID-19) Dashboard. [cited 25 May 2021]. Available from: https://covid19.who.int/
    1. Chan JF, Kok KH, Zhu Z, Chu H, To KK, Yuan S, Yuen KY. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect. 2020;9:221–236. - PMC - PubMed
    1. Greenough TC, Carville A, Coderre J, Somasundaran M, Sullivan JL, Luzuriaga K, Mansfield K. Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus. Am J Pathol. 2005;167:455–463. - PMC - PubMed
    1. Guo Y, Korteweg C, McNutt MA, Gu J. Pathogenetic mechanisms of severe acute respiratory syndrome. Virus Res. 2008;133:4–12. - PMC - PubMed
    1. Galanopoulos M, Gkeros F, Doukatas A, Karianakis G, Pontas C, Tsoukalas N, Viazis N, Liatsos C, Mantzaris GJ. COVID-19 pandemic: Pathophysiology and manifestations from the gastrointestinal tract. World J Gastroenterol. 2020;26:4579–4588. - PMC - PubMed