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. 2022 Aug 26;28(48):e202200906.
doi: 10.1002/chem.202200906. Epub 2022 Jul 4.

A Route to Lipid ALC-0315: a Key Component of a COVID-19 mRNA Vaccine

Fariba Saadati  1 , Silvia Cammarone  1 , Marco A Ciufolini  1
Affiliations

A Route to Lipid ALC-0315: a Key Component of a COVID-19 mRNA Vaccine

Fariba Saadati et al. Chemistry. .

Abstract

This paper describes a synthesis of ALC-0315 by a sequence that more than doubles the overall yield relative to the published one, and that employs much cleaner reactions, thereby facilitating purifications to a considerable extent.

Keywords: RNA therapeutics; lipids; reductive amination; vaccines.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Scheme 1
Scheme 1
Structure of ALC‐0315 and public‐domain synthesis thereof.
Scheme 2
Scheme 2
Preparation of compounds 3 and 5.
Scheme 3
Scheme 3
Synthesis of ALC‐0315, 1.
Scheme 4
Scheme 4
Synthesis of diol 11 and conversion thereof to 1.
See this image and copyright information in PMC

References

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