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. 2022 Jul 1;32(5):201-208.
doi: 10.1097/FPC.0000000000000474. Epub 2022 May 30.

PharmGKB summary: acyclovir/ganciclovir pathway

Maud Maillard  1 , Li Gong  2 , Rina Nishii  1 , Jun J Yang  1 , Michelle Whirl-Carrillo  2 , Teri E Klein  2   3
Affiliations

PharmGKB summary: acyclovir/ganciclovir pathway

Maud Maillard et al. Pharmacogenet Genomics. .
No abstract available

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Conflict of interest statement

Conflicts of interest

There are no conflicts of interest.

Figures

Figure 1:
Figure 1:
PharmGKB pathway for acyclovir/ganciclovir pharmacokinetics and pharmacodynamics. An interactive version of this pathway can be found at https://www.pharmgkb.org/pathway/PA166266401.
See this image and copyright information in PMC

References

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    1. Food and Drug Administration. Ganciclovir injection for intravenous use (highlights of prescribing information). 1989, revised February 2017. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209347lbl.pdf. Accessed 3/24/2022.
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    1. Nishii R, Mizuno T, Rehling D, Smith C, Clark BL, Zhao X, et al. NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir. Nat Commun 2021; 12:4181. - PMC - PubMed
    1. Zhang SM, Rehling D, Jemth AS, Throup A, Landázuri N, Almlöf I, et al. NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir. Cell Chem Biol 2021; 28:1693–1702.e1696. - PubMed

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