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Review
. 2022 Jun 3;101(22):e29471.
doi: 10.1097/MD.0000000000029471.

Malignant giant cell tumor of toe: A case report and review of literature

Kazuhiko Hashimoto  1 , Shunji Nishimura, Tomohiko Ito, Masao Akagi
Affiliations
Review

Malignant giant cell tumor of toe: A case report and review of literature

Kazuhiko Hashimoto et al. Medicine (Baltimore). .

Abstract

Introduction: A giant cell tumor of soft tissue (GCST) is a benign soft tissue tumor that often occurs subcutaneously in the extremities. Rare cases of malignant GCST have been reported, but its pathogenesis remains unclear.

Patients concerns: We report a case of a 68-year-old man who noticed a painless mass on his second toe one and a half years ago. He visited the Department of Dermatology at our hospital. Magnetic resonance imaging revealed a soft tissue tumor, surrounding the distal aspect of the second toe.

Diagnosis: A biopsy of the tumor was performed by a dermatologist, and it revealed a malignant giant cell tumor of the toe.

Interventions: He was referred to our department and underwent lay amputation for wide-margin resection.

Outcomes: No recurrence or metastasis was observed 5 years after treatment.

Conclusion: : Malignant GCST should be treated with wide-margin resection immediately after its diagnosis.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
(A) The radiograph showed a soft tissue shadow enhancement at the distal end of the second toe and lytic lesions (red arrowheads) in the intermediate and distal phalanges. (B) Coronal-view magnetic resonance imaging (MRI) revealed a low-intensity mass surrounding the second toe. Partial invasion of the tumor into the bone was observed. Red arrowheads indicate lytic lesions in the bones. (C) Sagittal-view MRI revealed a high-intensity mass surrounding the second toe. Partial invasion of the tumor into the bone was observed. Red arrowheads indicate lytic lesions in the bones.
Figure 2
Figure 2
(A) Histopathological findings of the biopsy in hematoxylin-eosin (H&E) staining in lower magnification (×200). (B) Histopathological findings of the biopsy in H&E staining in higher magnification (×400). (C) Histopathological findings of the specimen harvested during amputation in H&E staining in lower magnification (×400). (D) Histopathology revealed diffuse proliferation of atypical cells with enlarged round nuclei. Some multinucleated giant cells were also present. The Ki-67 positive cell rate was approximately 30%. (E) Immunohistochemical staining for CD-68 was observed. The scale bars = 100 μm.
Figure 3
Figure 3
The radiograph of the right foot after the surgical treatment.
See this image and copyright information in PMC

References

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