Expanding the heuristic neurocircuit-based taxonomy to guide treatment for OCD: reply to the commentary "Probing the genetic and molecular correlates of connectome alterations in obsessive-compulsive disorder"

Affiliations

¹ Department of Psychiatry, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. lizzieshephard@usp.br.
² Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College London, London, UK. lizzieshephard@usp.br.
³ Department of Psychiatry, The New York University School of Medicine, New York, NY, USA.
⁴ Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
⁵ Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
⁶ Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam, The Netherlands.
⁷ Department of Psychiatry, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
⁸ Department of Psychiatry OCD Clinic, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.
⁹ SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.
¹⁰ SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
¹¹ Center for OCD and Related Disorders, New York State Psychiatric Institute and the Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Comment

Elizabeth Shephard et al. Mol Psychiatry. 2022 Sep.

. 2022 Sep;27(9):3560-3561.

doi: 10.1038/s41380-022-01645-0. Epub 2022 Jun 3.

¹ Department of Psychiatry, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. lizzieshephard@usp.br.
² Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College London, London, UK. lizzieshephard@usp.br.
³ Department of Psychiatry, The New York University School of Medicine, New York, NY, USA.
⁴ Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
⁵ Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
⁶ Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam, The Netherlands.
⁷ Department of Psychiatry, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
⁸ Department of Psychiatry OCD Clinic, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.
⁹ SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.
¹⁰ SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
¹¹ Center for OCD and Related Disorders, New York State Psychiatric Institute and the Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

No abstract available

Comment on

Toward a neurocircuit-based taxonomy to guide treatment of obsessive-compulsive disorder.
Shephard E, Stern ER, van den Heuvel OA, Costa DLC, Batistuzzo MC, Godoy PBG, Lopes AC, Brunoni AR, Hoexter MQ, Shavitt RG, Reddy YCJ, Lochner C, Stein DJ, Simpson HB, Miguel EC. Shephard E, et al. Mol Psychiatry. 2021 Sep;26(9):4583-4604. doi: 10.1038/s41380-020-01007-8. Epub 2021 Jan 7. Mol Psychiatry. 2021. PMID: 33414496 Free PMC article. Review.
Probing the genetic and molecular correlates of connectome alterations in obsessive-compulsive disorder.
Saraiva LC, Sato JR, Cappi C. Saraiva LC, et al. Mol Psychiatry. 2022 Sep;27(9):3558-3559. doi: 10.1038/s41380-022-01590-y. Epub 2022 May 3. Mol Psychiatry. 2022. PMID: 35505088 No abstract available.

1. Shephard E, Stern ER, van den Heuvel OA, Costa DLC, Batistuzzo MC, Godoy PBG, et al. Toward a neurocircuit-based taxonomy to guide treatment of obsessive–compulsive disorder. Mol Psychiatry. 2021;26:4583–604. - DOI - PubMed - PMC
1. Shephard E, Batistuzzo MC, Hoexter MQ, Stern ER, Zuccolo PF, Ogawa CY, et al. Neurocircuit models of obsessive-compulsive disorder: limitations and future directions for research. Braz J Psychiatry. 2022;44:187–200.
1. Saraiva LC, Sato JR, Cappi C. Probing the genetic and molecular correlates of connectome alterations in obsessive-compulsive disorder. Mol Psychiatry (in press).
1. Grasby KL, Jahanshad N, Painter JN, Colodro-Conde L, Bralten J, Hibar DP, et al. The genetic architecture of the human cerebral cortex. Science. 2020;367:eaay6690. - DOI - PubMed - PMC
1. Mahjani B, Bey K, Boberg J, Burton C. Genetics of obsessive-compulsive disorder. Psychological Med. 2021;51:2247–59. - DOI