Synaptic plasticity during systems memory consolidation

Abstract

After learning, memory is initially encoded in the hippocampus but subsequently stabilized in other brain regions such as the cortex for long-lasting storage. This process is known as systems memory consolidation, and its cellular mechanism has long been a fundamental question. Synaptic plasticity is the major cellular mechanism underlying learning and memory, and is therefore considered a key function in the process of systems memory consolidation. Therefore, many studies have aimed to establish a causal link between synaptic plasticity in the brain and memory-associated behaviors. In this review, I discuss the various lines of research showing the function of synaptic plasticity, mainly in the hippocampus and cortex during memory consolidation.

Keywords: Anterior cingulate cortex; CALI; Hippocampus; Long-term potentiation; Optogenetics; Structural plasticity; Synaptic plasticity; Systems memory consolidation.