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Review
. 2022 Jul;38(3):505-519.
doi: 10.1016/j.ccc.2022.02.001. Epub 2022 Feb 28.

COVID-19 Acute Respiratory Distress Syndrome: One Pathogen, Multiple Phenotypes

Susannah Empson  1 , Angela J Rogers  2 , Jennifer G Wilson  3
Affiliations
Review

COVID-19 Acute Respiratory Distress Syndrome: One Pathogen, Multiple Phenotypes

Susannah Empson et al. Crit Care Clin. 2022 Jul.

Abstract

Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome arising from multiple causes with a range of clinical severity. In recent years, the potential for prognostic and predictive enrichment of clinical trials has been increased with identification of more biologically homogeneous subgroups or phenotypes within ARDS. COVID-19 ARDS also exhibits significant clinical heterogeneity despite a single causative agent. In this review the authors summarize the existing literature on COVID-19 ARDS phenotypes, including physiologic, clinical, and biological subgroups as well as the implications for improving both prognostication and precision therapy.

Keywords: ARDS; COVID-19; Phenotypes; Subtypes.

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Conflict of interest statement

Disclosure S. Empson has no conflict of interest to declare. A.J. Rogers is a pulmonary clinical trials advisor for Merck, not relevant to this work. J.G. Wilson has no conflict of interest to declare.

Figures

Fig. 1
Fig. 1
SARS-CoV-2 clinical course, viral replication, and immune response. (Adapted with permission from https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30230-7/fulltext.)
See this image and copyright information in PMC

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