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Review
. 2022 Jul;38(3):553-570.
doi: 10.1016/j.ccc.2022.03.002. Epub 2022 Mar 23.

Acute Neurologic Complications of COVID-19 and Postacute Sequelae of COVID-19

Neha S Dangayach  1 , Virginia Newcombe  2 , Romain Sonnenville  3
Affiliations
Review

Acute Neurologic Complications of COVID-19 and Postacute Sequelae of COVID-19

Neha S Dangayach et al. Crit Care Clin. 2022 Jul.

Abstract

Neurologic complications can be seen in mild to severe COVID-19 with a higher risk in patients with severe COVID-19. These can occur as a direct consequence of viral infection or consequences of treatments. The spectrum ranges from non-life-threatening, like headache, fatigue, malaise, anosmia, dysgeusia, to life-threatening complications, like stroke, encephalitis, coma, Guillain-Barre syndrome. A high index of suspicion can aid in early recognition and treatment. Outcomes depend on severity of underlying COVID-19, patient age, comorbidities, and severity of the complication. Postacute sequelae of COVID-19 range from fatigue, headache, dysosmia, brain fog, anxiety, depression to an overlap with postintensive care syndrome.

Keywords: Cerebrovascular complications; Long-COVID; Neuro-COVID; Neurologic complications.

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Conflict of interest statement

Disclosure The authors have no relevant conflicts of interest.

Figures

Fig. 1
Fig. 1
Potential mechanisms and complications of neuroCOVID.
Fig. 2
Fig. 2
Classifying neurologic complications of COVID-19. PNS, Peripheral Nervous System.
Fig. 3
Fig. 3
Common PASC symptoms.
See this image and copyright information in PMC

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