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Review
. 2022 Jul;38(3):571-586.
doi: 10.1016/j.ccc.2022.01.005. Epub 2022 Jan 10.

Severe COVID-19 and Multisystem Inflammatory Syndrome in Children in Children and Adolescents

Allison M Blatz  1 , Adrienne G Randolph  2
Affiliations
Review

Severe COVID-19 and Multisystem Inflammatory Syndrome in Children in Children and Adolescents

Allison M Blatz et al. Crit Care Clin. 2022 Jul.

Abstract

Severe complications related to COVID-19 occur infrequently in children and adolescents. these life-threatening complications are mainly acute respiratory failure from acute COVID-19 and multisystem inflammatory syndrome in children (MIS-C). MIS-C is a postinfectious complication occurring approximately 3 to 6 weeks mostly after an asymptomatic or mild SARS-CoV-2 infection. For both types of complications, supportive ICU care is often required. For MIS-C critical illness, immunomodulation is prescribed to reverse hyperinflammation and its cardiac and other sequelae.

Keywords: COVID-19; MIS-C; Multisystem inflammatory syndrome; Pediatrics.

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Figures

Fig. 1
Fig. 1
Daily cases of Multisystem Inflammatory Syndrome in Children (MIS-C) in the U.S. reported to the Centers for Disease Control and Prevention (CDC) from the state public health departments in relation to reported pediatric cases of COVID-19.
See this image and copyright information in PMC

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Supplementary concepts