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Review
. 2022 Aug;40(8):907-909.
doi: 10.1016/j.tibtech.2022.05.002. Epub 2022 Jun 3.

Prime editor integrase systems boost targeted DNA insertion and beyond

Ayman Eid  1 , Yiping Qi  2
Affiliations
Review

Prime editor integrase systems boost targeted DNA insertion and beyond

Ayman Eid et al. Trends Biotechnol. 2022 Aug.

Abstract

Previously developed genome engineering tools cannot efficiently direct site-specific long DNA insertion. Built on the prime editing platform, two recent studies have reported integrase-mediated site-specific long DNA integration in the human genome. These prime editor integrase (PEI) systems will unleash many exciting applications in humans, animals, and plants.

Keywords: BxbI; DNA insertion; PASTE; TwinPE; integrase; prime editor.

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Conflict of interest statement

Declaration of interests The authors declare no conflict of interests.

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