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Comparative Study
. 1987 Mar;23(3):355-7.
doi: 10.1111/j.1365-2125.1987.tb03058.x.

Age-related changes in trimethadione oxidizing capacity

E Tanaka, A Ishikawa, A Ono, T Okamura, S Misawa
Comparative Study

Age-related changes in trimethadione oxidizing capacity

E Tanaka et al. Br J Clin Pharmacol. 1987 Mar.

Abstract

The metabolism of trimethadione (TMO) following oral administration (4 mg kg-1) has been studied in 11 young male and 11 elderly male patients. The elimination half-life (h) of TMO was 11.8 +/- 1.4 (mean +/- s.e. mean) in the young and 23.5 +/- 2.17 in the elderly (P less than 0.01). Total body clearance (1 h-1 kg-1) was 41.4 +/- 2.8 in the young and 29.0 +/- 2.4 in the elderly (P less than 0.01). The apparent volume of distribution (1 kg-1) was 0.67 +/- 0.03 in the young and 0.65 +/- 0.04 in the elderly. Serum dimethadione (DMO)/TMO ratios at 4 h were 0.65 +/- 0.03 in the young and 0.46 +/- 0.03 in the elderly (P less than 0.01). These results suggest that N-demethylation of TMO is inversely related to age.

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References

    1. Clin Pharmacol Ther. 1975 Oct;18(4):425-32 - PubMed
    1. J Pharmacol Exp Ther. 1982 Jan;220(1):120-6 - PubMed
    1. Hepatology. 1982 Jan-Feb;2(1):97-105 - PubMed
    1. Br J Clin Pharmacol. 1982 Nov;14(5):631-51 - PubMed
    1. J Pharmacobiodyn. 1986 Mar;9(3):297-302 - PubMed

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