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. 2023 Mar;168(3):269-281.
doi: 10.1177/01945998221105059. Epub 2023 Jan 24.

Kaposi Sarcoma of the Larynx: A Systematic Review

Kendyl Barron  1 , Ariel Omiunu  1 , Joseph Celidonio  1 , Alexandra Cruz-Mullane  1 , Corina Din-Lovinescu  1 , Maria Manuela Chemas-Velez  2 , Soly Baredes  1   3 , Jean Anderson Eloy  1   3   4   5   6 , Christina H Fang  7
Affiliations

Kaposi Sarcoma of the Larynx: A Systematic Review

Kendyl Barron et al. Otolaryngol Head Neck Surg. 2023 Mar.

Abstract

Objective: Kaposi sarcoma (KS) of the larynx is a rare disease with few cases reported in the literature. This study aims to provide a comprehensive review of laryngeal KS, including patient characteristics, treatment, and clinical outcomes.

Data sources: PubMed, CINAHL, SCOPUS, and Cochrane Library.

Review methods: A systematic review of the published English literature was conducted. An electronic search and bibliographic examination of articles pertaining to laryngeal KS were performed. Demographic data, tumor site, treatment strategies, follow-up, and outcome were analyzed.

Results: A total 77 cases from 50 articles were included in the review. The mean age was 47.6 years (range, 8-81). There was an 8.6:1 male:female ratio. The most common presenting symptoms were dyspnea (n = 35) and hoarseness (n = 25). Laryngeal KS arose most frequently in the supraglottic region (n = 16). Chemotherapy alone (n = 27) was the most common treatment modality in patients with AIDS-associated KS, and surgical excision alone (n = 7) was most common in patients with other subtypes of KS (eg, classic, transplant associated). Average follow-up was 20.4 months (range, 0.75-120). Most patients with AIDS-associated KS died of other causes (n = 25), but most patients with other subtypes of KS were alive with no evidence of disease at follow-up (n = 13).

Conclusion: This review contains the largest pool of laryngeal KS cases to date. Long-term outcomes were generally unfavorable, often due to advanced HIV disease at the time of diagnosis.

Keywords: AIDS; HIV; Kaposi sarcoma; chemotherapy; human herpesvirus 8; larynx; radiotherapy; surgical management; systematic review.

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References

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