Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2022 Oct 15;206(8):999-1007.
doi: 10.1164/rccm.202111-2657OC.

Coarse Particulate Air Pollution and Daily Mortality: A Global Study in 205 Cities

Cong Liu  1 , Jing Cai  1 , Renjie Chen  1 , Francesco Sera  2 , Yuming Guo  3   4 , Shilu Tong  5   6   7   8 , Shanshan Li  3 , Eric Lavigne  9   10 , Patricia Matus Correa  11 , Nicolas Valdes Ortega  12 , Hans Orru  13   14 , Marek Maasikmets  15 , Jouni J K Jaakkola  16 , Niilo Ryti  16 , Susanne Breitner  17 , Alexandra Schneider  17 , Klea Katsouyanni  18   19 , Evangelia Samoli  18 , Masahiro Hashizume  20 , Yasushi Honda  21 , Chris Fook Sheng Ng  20   22 , Magali Hurtado Diaz  23 , César De la Cruz Valencia  23 , Shilpa Rao  24 , Alfonso Diz-Lois Palomares  24 , Susana Pereira da Silva  25 , Joana Madureira  25   26   27 , Iulian Horia Holobâc  28 , Simona Fratianni  29 , Noah Scovronick  30 , Rebecca M Garland  31 , Aurelio Tobias  22   32 , Carmen Íñiguez  33   34 , Bertil Forsberg  13 , Christofer Åström  13 , Ana Maria Vicedo-Cabrera  35   36 , Martina S Ragettli  37   38 , Yue-Liang Leon Guo  39   40 , Shih-Chun Pan  40 , Ai Milojevic  41 , Michelle L Bell  42 , Antonella Zanobetti  43 , Joel Schwartz  43 , Antonio Gasparrini  41   44   45 , Haidong Kan  1   46
Affiliations
Meta-Analysis

Coarse Particulate Air Pollution and Daily Mortality: A Global Study in 205 Cities

Cong Liu et al. Am J Respir Crit Care Med. .

Abstract

Rationale: The associations between ambient coarse particulate matter (PM2.5-10) and daily mortality are not fully understood on a global scale. Objectives: To evaluate the short-term associations between PM2.5-10 and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide. Methods: We collected daily mortality (total, cardiovascular, and respiratory) and air pollution data from 205 cities in 20 countries/regions. Concentrations of PM2.5-10 were computed as the difference between inhalable and fine PM. A two-stage time-series analytic approach was applied, with overdispersed generalized linear models and multilevel meta-analysis. We fitted two-pollutant models to test the independent effect of PM2.5-10 from copollutants (fine PM, nitrogen dioxide, sulfur dioxide, ozone, and carbon monoxide). Exposure-response relationship curves were pooled, and regional analyses were conducted. Measurements and Main Results: A 10 μg/m3 increase in PM2.5-10 concentration on lag 0-1 day was associated with increments of 0.51% (95% confidence interval [CI], 0.18%-0.84%), 0.43% (95% CI, 0.15%-0.71%), and 0.41% (95% CI, 0.06%-0.77%) in total, cardiovascular, and respiratory mortality, respectively. The associations varied by country and region. These associations were robust to adjustment by all copollutants in two-pollutant models, especially for PM2.5. The exposure-response curves for total, cardiovascular, and respiratory mortality were positive, with steeper slopes at lower exposure ranges and without discernible thresholds. Conclusions: This study provides novel global evidence on the robust and independent associations between short-term exposure to ambient PM2.5-10 and total, cardiovascular, and respiratory mortality, suggesting the need to establish a unique guideline or regulatory limit for daily concentrations of PM2.5-10.

Keywords: PM2.5-10; air pollution; mortality; multicenter study; time-series study.

PubMed Disclaimer

Comment in

Publication types

LinkOut - more resources