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Multicenter Study
. 2023 Feb;51(2):163-171.
doi: 10.1016/j.ajic.2022.05.025. Epub 2022 Jun 5.

Correlation between antibiotic use and antibiotic resistance: A multicenter study using the Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system in Hokkaido, Japan

Keisuke Kagami  1 , Nobuhisa Ishiguro  2 , Sumio Iwasaki  3 , Takayuki Usami  3 , Tatsuya Fukumoto  3 , Kasumi Hayasaka  3 , Reiko Oyamada  2 , Tsubasa Watanabe  2 , Sho Nakakubo  4 , Yusuke Niinuma  5 , Takashi Hagino  6 , Yoshifumi Abe  6 , Ikuya Fujimoto  7 , Hideki Maekawa  8 , Ryo Fujibayashi  8 , Satoshi Fuke  9 , Kuniko Asahi  10 , Shuichi Ota  11 , Tatsuya Nagakura  12 , Toshinari Okubo  13 , Hideomi Asanuma  14 , Toshihiro Ito  15 , Sho Okano  16 , Erika Komatsu  17 , Kota Sasaki  18 , Kei Hashimoto  19 , Kazutoshi Washiya  19 , Yumiko Kato  20 , Katsunori Kusumi  21 , Yasufumi Asai  22 , Yuichi Saito  23 , Yoshiyuki Sakai  24 , Minoru Sakurada  25 , Yuji Sakimoto  26 , Yukari Ichikawa  27 , Takahiro Kinebuchi  28 , Dai Kondo  29 , Syuhei Kanno  30 , Minoru Kobayashi  31 , Kagami Hirabayashi  32 , Shinako Saitou  33 , Katsuhiko Saito  34 , Yuuki Ebina  35 , Yuusuke Koshizaki  36 , Makoto Chiba  37 , Atsushi Yasuda  38 , Toshiya Sato  39 , Atsuo Togashi  39 , Takashi Abe  40 , Takahiro Fujita  41 , Kengo Umehara  42 , Masaru Amishima  43 , Nobuo Murakami  44 , Tetsuya Yagi  45 , Shuhei Fujimoto  46 , Taichi Tajima  47 , Mitsuru Sugawara  48 , Yoh Takekuma  49
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Free article
Multicenter Study

Correlation between antibiotic use and antibiotic resistance: A multicenter study using the Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system in Hokkaido, Japan

Keisuke Kagami et al. Am J Infect Control. 2023 Feb.
Free article

Abstract

Background: The Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system aggregates information related to antimicrobial resistance (AMR) measures in participating medical institutions nationwide and is intended to be used for promotion of AMR measures in participating facilities and their communities. This multicenter study aimed to determine the usefulness of the J-SIPHE system for evaluating the correlation between antibiotic use and antibiotic resistance in Hokkaido, Japan.

Methods: Data on antibiotic use and detection rate of major resistant Gram-negative bacteria at 19 hospitals in 2020 were collected from the J-SIPHE system, and data correlations were analyzed using JMP Pro.

Results: The detection rate of carbapenem-resistant Pseudomonas aeruginosa was significantly positively correlated with carbapenem use (Spearman's ρ = 0.551; P = .015). There were significant positive correlations between the detection rate of fluoroquinolone-resistant Escherichia coli and the use of piperacillin/tazobactam, carbapenems, and quinolones [ρ = 0.518 (P = .023), ρ = 0.76 (P < .001), and ρ = 0.502 (P = .029), respectively].

Conclusions: This is the first multicenter study to investigate the correlation between antibiotic use and antibiotic resistance using the J-SIPHE system. The results suggest that using this system may be beneficial for promoting AMR measures.

Keywords: AMR; Antimicrobial resistance; Antimicrobial stewardship; Carbapenems; Quinolones.

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