Cadmium exposure and the risk of GDM: evidence emerging from the systematic review and meta-analysis
- PMID: 35672642
- DOI: 10.1007/s11356-022-21171-4
Cadmium exposure and the risk of GDM: evidence emerging from the systematic review and meta-analysis
Abstract
Gestational diabetes mellitus (GDM) has become a global concern for its severe adverse effects on both mother and fetus. Recent epidemiological studies reported inconsistent results of the association between cadmium (Cd) exposure and GDM. Therefore, a systematic review and meta- analysis were performed. PubMed, Web of Science, Scopus, Embase, and SpringerLink were searched up to July 2021. Observational studies containing the adjusted relative risks between Cd exposure and GDM were included in the quantitative synthesis. The retrieval comprised 218 articles out of which 11 met our criteria and 9 were included in the meta-analysis, representing a total of 32,392 subjects (2881 GDM). In total, Cd exposure might increase the risk of GDM in some extent (OR = 1.21, 95% CI [0.89, 1.64]), even without statistical significance in high heterogeneity (Q = 28.45, p < 0.05, I2 = 71.9%). Filtering two outliers indicated by Galbraith plot yielded a similar risk (OR = 1.19, 95% CI [1.02, 1.39]) with statistical significance. However, the heterogeneity among studies was obviously reduced (Q = 11.75, p = 0.068, I2 = 48.9%). Additionally, biological specimen, study design, and diagnostic criteria contributed to the high heterogeneity according to the subgroup analysis. Since some important results do not deny that Cd exposure increases the risk of GDM, high-quality multi-centered large cohort studies are required in the future.
Keywords: Cadmium; Gestational diabetes mellitus; Heavy metal; Pregnancy; Risk factor.
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Similar articles
-
The Association Between Cadmium Exposure and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis.Front Public Health. 2022 Feb 10;9:555539. doi: 10.3389/fpubh.2021.555539. eCollection 2021. Front Public Health. 2022. PMID: 35223753 Free PMC article.
-
Relation between cadmium exposure and gestational diabetes mellitus.Environ Int. 2018 Apr;113:300-305. doi: 10.1016/j.envint.2018.01.001. Epub 2018 Jan 17. Environ Int. 2018. PMID: 29338949
-
Environmental health influences in pregnancy and risk of gestational diabetes mellitus: a systematic review.BMC Public Health. 2022 Aug 18;22(1):1572. doi: 10.1186/s12889-022-13965-5. BMC Public Health. 2022. PMID: 35982427 Free PMC article.
-
Ambient air pollution and gestational diabetes mellitus: A review of evidence from biological mechanisms to population epidemiology.Sci Total Environ. 2020 Jun 1;719:137349. doi: 10.1016/j.scitotenv.2020.137349. Epub 2020 Feb 15. Sci Total Environ. 2020. PMID: 32114225 Review.
-
Cadmium Body Burden and Gestational Diabetes Mellitus: A Prospective Study.Environ Health Perspect. 2018 Feb 8;126(2):027006. doi: 10.1289/EHP2716. Environ Health Perspect. 2018. PMID: 29425094 Free PMC article.
Cited by
-
Correlation between TCF7L2 and CAPN10 gene polymorphisms and gestational diabetes mellitus in different geographical regions: a meta-analysis.BMC Pregnancy Childbirth. 2024 Jan 2;24(1):15. doi: 10.1186/s12884-023-06177-1. BMC Pregnancy Childbirth. 2024. PMID: 38166877 Free PMC article. Review.
-
Recent advances in the application of ionomics in metabolic diseases.Front Nutr. 2023 Jan 16;9:1111933. doi: 10.3389/fnut.2022.1111933. eCollection 2022. Front Nutr. 2023. PMID: 36726817 Free PMC article. Review.
-
Vitamin E Intake Attenuated the Association Between Elevated Blood Heavy Metal (Pb, Cd, and Hg) Concentrations and Diabetes Risk in Adults Aged 18-65 Years: Findings from 2007-2018 NHANES.Toxics. 2024 Dec 25;13(1):9. doi: 10.3390/toxics13010009. Toxics. 2024. PMID: 39853009 Free PMC article.
References
-
- Al Doghaither H, Elmorsy E, Al-Ghafari A, Ghulam J (2021) Roles of oxidative stress, apoptosis, and inflammation in metal-induced dysfunction of beta pancreatic cells isolated from CD1 mice. Saudi J Biol Sci 28:651–663 - DOI
-
- Alberti K, Zimmet P (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabet Med 15:539–53
-
- American Diabetes A (2011) Standards of medical care in diabetes–2011. Diabetes Care 34(Suppl 1):S11-61 - DOI
-
- American Diabetes A (2021) 2. Classification and diagnosis of diabetes: Standards of Medical Care in Diabetes-2021. Diabetes Care 44:S15–S33 - DOI
-
- Archambault C, Arel R, Filion KB (2014) Gestational diabetes and risk of cardiovascular disease: a scoping review. Open Med 8:e1-9
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Miscellaneous