Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr 13;21(1):717-725.
doi: 10.1007/s40200-022-01040-0. eCollection 2022 Jun.

Bone mass and microarchitecture in T2DM patients and corticosteroids therapy: the Bushehr Elderly Health program

Safoora Gharibzadeh  1 , Golnaz Goodarzi  2 , Sadra Samavarchi Tehrani  2 , Noushin Fahimfar  3 , Farideh Razi  4   5 , Mahnaz Sanjari  3 , Kazem Khalagi  3   6 , Gita Shafiee  7 , Ramin Heshmat  7 , Azam Amini  8 , Iraj Nabipour  9 , Bagher Larijani  10 , Afshin Ostovar  3
Affiliations

Bone mass and microarchitecture in T2DM patients and corticosteroids therapy: the Bushehr Elderly Health program

Safoora Gharibzadeh et al. J Diabetes Metab Disord. .

Abstract

Purpose: Our study examined whether T2DM and glucocorticoids treatment affect bone quality and quantity that are measured by Bone Mineral Density (BMD) and Trabecular Bone Score (TBS).

Materials & methods: Participants in this study were 2294 women and men aged over 60 years who participated in stage II of the Bushehr Elderly Health (BEH) program. Patients with T2DM and those who received glucocorticoids were included. BMD was detected using the DXA method and the TBS of L1-L4 was evaluated by TBS iNsight® software. To evaluate the correlation between TBS and BMD levels with diabetes and taking corticosteroids sex-specific multivariable linear regression models were appplied.

Results: TBS and BMD were not significantly different in those who had received glucocorticoids versus those who did not.T2DM revealed a significant association with both BMD and TBS in men (beta = 0.12, p < 0.001 and beta = 0.063, p = 0.03, respectively). BMD values were significantly higher in diabetic women (beta = 0.073, p < 0.01). BMI had a significant association with both TBS and BMD but in an opposite direction, in women and men (BMD: beta = -0.22, -0.24, and regarding TBS: beta = 0.37, 0.25, all p-values < 0.001).

Conclusion: Our findings showed that T2DM had major effects on BMD in both men and women. However, T2DM only affects TBS in men. Furthermore, neither BMD nor TBS were affected by GC intake in men or women.Based on the variable importance of covariates, BMI was the most influential factor on both BMD and TBS, although in opposite directions, in both sexes.

Keywords: And Trabecular bone score; Bone Mineral Density; Elderly; Glucocorticoids; Iran; Type 2 diabetes mellitus.

PubMed Disclaimer

Conflict of interest statement

Conflict of InterestNone.

References

    1. Xue Y, Baker AL, Nader S, Orlander P, Sanchez AJ, Kellam J, et al. Lumbar spine trabecular bone score (TBS) reflects diminished bone quality in patients with diabetes mellitus and oral glucocorticoid therapy. J Clin Densitom. 2018;21(2):185–192. doi: 10.1016/j.jocd.2017.09.003. - DOI - PubMed
    1. Hamann C, Kirschner S, Günther K-P, Hofbauer LC. Bone, sweet bone—osteoporotic fractures in diabetes mellitus. Nat Rev Endocrinol. 2012;8(5):297–305. doi: 10.1038/nrendo.2011.233. - DOI - PubMed
    1. Tehrani SS, Moallem M, Ebrahimi R, Hosseini SR, Nooreddini H, Parsian H. Status of circulating bone turnover markers in elderly osteoporosis/osteopenia patients in comparison with healthy subjects. Asian Biomedicine. 2020;14(3):97–106. doi: 10.1515/abm-2020-0015. - DOI
    1. Tootee A, Larijani B. World osteoporosis day: celebrating two decades of progress in preventing osteoporotic fractures in Iran. J Diabetes Metab Disord. 2019;18(2):725–727. doi: 10.1007/s40200-019-00465-4. - DOI - PMC - PubMed
    1. Nazrun AS, Tzar MN, Mokhtar SA, Mohamed IN. A systematic review of the outcomes of osteoporotic fracture patients after hospital discharge: morbidity, subsequent fractures, and mortality. Ther Clin Risk Manag. 2014;10:937. - PMC - PubMed

LinkOut - more resources