Genomic medicine on the frontier of precision medicine

Mandana Hasanzad^{1

2}, Negar Sarhangi², Anoosh Naghavi³, Ehsan Ghavimehr¹, Fatemeh Khatami⁴, Sima Ehsani Chimeh⁵, Bagher Larijani⁶, Hamid Reza Aghaei Meybodi²

Affiliations

¹ Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
² Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, No.10- Jalal -e-Ale-Ahmad Street, Chamran Highway, 1411713119 Tehran, Iran.
³ Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
⁴ Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
⁵ University of Arizona Cancer Center, Tucson, AZ USA.
⁶ Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 35673457
PMCID: PMC9167337
DOI: 10.1007/s40200-021-00880-6

Review

Genomic medicine on the frontier of precision medicine

Mandana Hasanzad et al. J Diabetes Metab Disord. 2021.

. 2021 Aug 24;21(1):853-861.

doi: 10.1007/s40200-021-00880-6. eCollection 2022 Jun.

Authors

Mandana Hasanzad^{1

2}, Negar Sarhangi², Anoosh Naghavi³, Ehsan Ghavimehr¹, Fatemeh Khatami⁴, Sima Ehsani Chimeh⁵, Bagher Larijani⁶, Hamid Reza Aghaei Meybodi²

Affiliations

¹ Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
² Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, No.10- Jalal -e-Ale-Ahmad Street, Chamran Highway, 1411713119 Tehran, Iran.
³ Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
⁴ Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
⁵ University of Arizona Cancer Center, Tucson, AZ USA.
⁶ Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 35673457
PMCID: PMC9167337
DOI: 10.1007/s40200-021-00880-6

Abstract

Genomic medicine has created a great deal of hope since the completion of the Human Genome Project (HGP). Genomic medicine promises disease prevention and early diagnosis in the context of precision medicine. Precision medicine as a scientific discipline has introduced as an evolution in medicine. The rapid growth of high-development technologies permits the assessment of biological systems. Study of the integrated profiles of omics, such as genome, transcriptome, proteome and other omics information lead to significant advances in personalized and precision medicine. In the context of precision medicine, pharmacogenomics can play an important role in order to discriminate responders and non-responders to medications and avoiding toxicity and achieving the optimum dose. So precision medicine in accordance with genomic medicine will transform medicine from conventional evidence-based medicine in the diagnosis and treatment towards precision based-medicine. In this review, we have summarized the related issues for genomic medicine and precision medicine.

Keywords: GWAS; Genomic medicine; Omics; Pharmacogenomics; Precision medicine.

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Conflict of interest statement

Conflict of interestThe authors declare that they have no conflict of interest.

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Genomic medicine on the frontier of precision medicine

Affiliations

Genomic medicine on the frontier of precision medicine

Authors

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Abstract

Conflict of interest statement

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