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. 2022 May 14;21(1):743-750.
doi: 10.1007/s40200-022-01044-w. eCollection 2022 Jun.

The impact of zinc supplementation on galectin-3 and metabolic markers in diabetic patients on hemodialysis: A randomized, double-blind, placebo-controlled trial

Razieh Hosseini  1 , Mansour Karajibani  2 , Farzaneh Montazerifar  3 , Elham Shahraki  4 , Khatereh Babakhani  5 , Ali Mohammad Mokhtari  6 , Amirhossein Sahebkar  7   8
Affiliations

The impact of zinc supplementation on galectin-3 and metabolic markers in diabetic patients on hemodialysis: A randomized, double-blind, placebo-controlled trial

Razieh Hosseini et al. J Diabetes Metab Disord. .

Abstract

Purpose: There is little information about the association between zinc sulfate (ZnSO4) supplementation and metabolic profiles in zinc-deficient diabetic patients on hemodialysis (DHPs). Therefore, we aimed to investigate the association between ZnSO4 supplementation and serum levels of galectin-3 (Gal-3) and cardiometabolic parameters in zinc-deficient DHPs.

Methods: In the present randomized double-blind placebo-controlled clinical trial, 46 zinc-deficient DHPs (35-62 years) were included and assigned to receive either 220 mg/d ZnSO4 or placebo for 8 weeks. Serum levels of Gal-3, lipid profile, and blood pressure (BP) were assessed at baseline and the end of trial.

Results: We found a significant effect of ZnSO4 intake on the reduction of serum Gal-3 (P = < 0.001), triglycerides (P = < 0.001), total cholesterol (P = < 0.001), low-density lipoprotein cholesterol (P = < 0.001) and increased high-density lipoprotein cholesterol (P = < 0.001) as compared to the control group. Additionally, systolic blood pressure (SBP) (P = 0.006) and diastolic blood pressure (DBP) (P = 0.01) were significantly reduced following 8 weeks of ZnSO4 supplementation.

Conclusion: Taken together, 220 mg ZnSO4 supplementation per day for 8 weeks among zinc-deficient DHPs had beneficial effects on Gal-3 and metabolic profiles.

Iranian registry of clinical trials identifier: IRCT20191217045765N1, date of registration: 2020-02-09.

Keywords: Cardiometabolic parameters; Diabetic nephropathy; Galectin-3; Zinc.

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Conflict of interest statement

Conflict of interestThe authors declare that they have no competing interests.

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