Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Feb 10;21(1):439-444.
doi: 10.1007/s40200-022-00990-9. eCollection 2022 Jun.

Association between engulfment and cell motility 1-gene polymorphisms and diabetic nephropathy in an Egyptian population with type 2 diabetes

Maggie S El Nahid  1 , Amal Fouad Mohamed Al-Ganiny  2 , Rasha Nazih Youssef  3
Affiliations

Association between engulfment and cell motility 1-gene polymorphisms and diabetic nephropathy in an Egyptian population with type 2 diabetes

Maggie S El Nahid et al. J Diabetes Metab Disord. .

Abstract

Purpose: Engulfment and cell motility 1 (ELMO1), is a candidate gene responsible for cell motility and phagocytosis. However, its role in the development and progression of nephropathy attributed to T2D is still unknown. Kidney injury molecule-1 (KIM-1) plays a significant role in renal regeneration processes. The current study aimed to evaluate the association between kidney injury molecule-1 levels, ELMO1 gene polymorphism (rs741301, and rs1345365) as well as DN in an Egyptian population with T2D.

Methods: In this study, we enrolled 89 participants from the internal medicine outpatient clinic, 23 T2DM without DN, 22 with DN, and 44 control subjects. They were genotyped by real-time PCR. Serum level of KIM-1 was detected by ELISA.

Results: Serum KIM-1 level was correlated with DM duration, HbA1C, and UACR (P value <0.001) in T2D. There was no significant difference in the allelic and genotypic frequencies of rs741301 and rs1345365 between participants with DM who presented with albuminuria and those without. Results showed that rs1345365A/rs741301T and rs1345365G/rs741301C haplotypes were more common in patients with T2D than in HCs. However, the difference was not statistically significant (P = 0.262 and 0.414, respectively).

Conclusions: KIM-1 can be a useful non-invasive biomarker for detecting early DN. The association between ELMO1 gene polymorphisms and the risk of DN in patients with T2D was not validated. Therefore, further studies with a larger sample size must be conducted.

Keywords: Diabetic nephropathy; ELMO1; Genotyping; KIM-1.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interests/Competing interestsThe authors have no competing interests to declare that are relevant to the content of this article.

Similar articles

See all similar articles

Cited by

References

    1. Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018;14(2):88–98. doi: 10.1038/nrendo.2017.151. - DOI - PubMed
    1. Temelkova-Kurktschiev T, Stefanov T. Lifestyle and genetics in obesity and type 2 diabetes. Exp Clin Endocrinol Diabetes. 2012;120:1–6. doi: 10.1055/s-0031-1285832. - DOI - PubMed
    1. Singh G, Sharma R, Raina P, et al. Association of Genetic Variants of ELMO1&nbsp;gene with diabetic nephropathy in the north Indian Population, 2020 , PREPRINT (Version 1) available at Research Square. 10.21203/rs.3.rs-121795/v1.
    1. Mehrabzadeh M, Pasalar P, Karimi M, Abdollahi M, Daneshpour M, Asadolahpour E, Razi F. Association between ELMO1 gene polymorphisms and diabetic nephropathy in an Iranian population. J Diabetes Metab Disord. 2016;7(15):43. - PMC - PubMed
    1. Shimazaki A, Tanaka Y, Shinosaki T, Ikeda M, Watada H, Hirose T. ELMO1 increases expression of extracellular matrix proteins and inhibits cell adhesion to ECMs. Kidney Int. 2006;70:1769–1776. doi: 10.1038/sj.ki.5001939. - DOI - PubMed

LinkOut - more resources