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. 2022 May 20;42(5):766-771.
doi: 10.12122/j.issn.1673-4254.2022.05.20.

[Neural mechanism for modulation of auditory response of the striatum by locomotion]

[Article in Chinese]
W Huang  1 , F Liang  1
Affiliations

[Neural mechanism for modulation of auditory response of the striatum by locomotion]

[Article in Chinese]
W Huang et al. Nan Fang Yi Ke Da Xue Xue Bao. .

Abstract
in English, Chinese

Objective: To explore whether the characteristic responses to sound stimulations of the auditory neurons in the striatum is regulated in different behavioral states.

Methods: The auditory neurons in the striatum of awake C57BL/6J mice were selected for this study. We recorded the auditory response of the striatum to noises over a long period of time by building a synchronous in vivo electrophysiological and locomotion recording system and using glass microelectrode attachment recording. By analyzing the running speed of the mice, the behavioral states of the mice were divided into the quiet state and the active state, and the spontaneous activity and evoked responses of the auditory neurons in the striatum were analyzed in these two states.

Results: Compared with those recorded in the quiet state, the spontaneous activity of the auditory neurons in the striatum of the mice increased significantly (37.06±12.02 vs 18.51±10.91, P < 0.001) while the auditory response of the neurons decreased significantly (noise intensity=60 dB, 3.45±2.99 vs 3.04±2.76, P < 0.001) in the active state.

Conclusion: Locomotion has a significant inhibitory effect on the auditory response of the striatum, which may importantly contribute to the decline of sound information recognition ability in the active state.

目的: 研究动物处于不同行为状态时，纹状体听觉神经元对声音信息的特征表达是否被调控。

方法: 以SPF级C57BL/6J清醒小鼠纹状体的听觉神经元为研究对象，通过搭建同步的在体电生理和运动记录系统，采用玻璃微电极贴附式记录方法长时间记录纹状体听觉神经元对噪声的听觉响应，并通过分析小鼠跑动速度将小鼠的行为状态分为安静状态和运动状态，分析动物处于两种行为状态下纹状体听觉神经元的自发活动和诱发响应。

结果: 相对于安静状态，当动物处于运动状态时，纹状体听觉神经元的自发活动增高（37.06±12.02 vs 18.51±10.91，P < 0.001），而诱发响应下降（噪声强度=60 dB，3.45±2.99 vs 3.04±2.76，P < 0.001）。

结论: 运动状态对纹状体的听觉响应具有显著的抑制作用，这可能是导致运动状态时声音信息的识别能力下降的重要原因。

Keywords: auditory neurons; auditory response; locomotion modulation; striatum.

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Figures

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运动对于纹状体神经元spontaneous的调制 Modulation of spontaneous firing of the neurons in the striatum by locomotion. A: Experimental setup (R, recording electrode; V, velocity. P, head-fixation post). B: Calculation model. C: Upper, spontaneous spikes recorded from a striatum cell (scale bar=0.1 s); Lower, concurrently recorded plate rotation speed (scale bar=10 cm/s). D: Summary of recordings from 21 striatum cells in quiet state (Q) vs active state (A). ***P < 0.001, paired t-test.
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2
纹状体在运动状态下和安静状态下的声音响应对比 Acoustic responses in quiet state vs active state in the striatum. A: Responses of a neuron in the striatum to 60-20 dB noises in the quiet state. Gray Bar represents the duration (50 ms) of noise. B: Evoked-spikes vs intensity curve in the quiet state for the same neuron. C: Responses of the same neuron to 60-20 dB noises in the active state. D: Evoked-spikes vs intensity curve in the active state for the same neuron.
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3
运动对于纹状体神经元的声响应调制 Modulation of acoustic responses of the neurons in the striatum by locomotion. A-C: Evoked-spikes by 60, 50 and 40 dB noises recorded from 21 striatum cells in the quiet (Q) state vs active (A) state, respectively. ***P < 0.001 by paired t-test. Error bars represent SD in all panels. D: Comparison of evoked-spikes vs intensity curves in the quiet state (black triangle) and the active state (red triangle). Error bars represent SD.
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