Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Nov;47(11):3213-3220.
doi: 10.1007/s11064-022-03645-6. Epub 2022 Jun 8.

Lipoxygenase Metabolism: Critical Pathways in Microglia-mediated Neuroinflammation and Neurodevelopmental Disorders

Shuli Chen  1 , Haidong Zou  2   3   4   5
Affiliations
Review

Lipoxygenase Metabolism: Critical Pathways in Microglia-mediated Neuroinflammation and Neurodevelopmental Disorders

Shuli Chen et al. Neurochem Res. 2022 Nov.

Abstract

As innate immune cells of the central nervous system (CNS), microglia are involved in the physiological processes of the CNS, including neural development and maintenance of homeostasis, and in the occurrence and development of most CNS diseases. Lipoxygenases (LOXs) are a family of non-heme, iron-containing enzymes that generate lipid mediators that regulate cellular inflammation by catalyzing the oxidation of polyunsaturated fatty acids. Many previous studies have demonstrated the indispensable role of the LOX pathway in microglia-mediated neuroinflammation, especially the 5-LOX and 12/15-LOX pathways. Emerging evidence indicates that the LOX pathway is also implicated in physiological processes, such as synaptic pruning and synaptic phagocytosis mediated by microglia, and that deficiency can contribute to neurodevelopmental disorders. The present review summarizes the impact of the LOX pathway on microglia-related physiological and pathological processes in the CNS and describes the potential for inhibition of the LOX pathway as a future strategy for the treatment of CNS diseases.

Keywords: 12/15-lipoxygenase; 5-lipoxygenase; Microglia; Neurodevelopmental disorders; Neuroinflammation.

PubMed Disclaimer

References

    1. Prinz M, Jung S, Priller J (2019) Microglia biology: one century of evolving concepts. Cell 179(2):292–311. https://doi.org/10.1016/j.cell.2019.08.053 - DOI - PubMed
    1. Ginhoux F, Prinz M (2015) Origin of microglia: current concepts and past controversies. Cold Spring Harb Perspect Biol 7(8):a020537. https://doi.org/10.1101/cshperspect.a020537 - DOI - PubMed - PMC
    1. Frost JL, Schafer DP (2016) Microglia: architects of the developing nervous system. Trends Cell Biol 26(8):587–597. https://doi.org/10.1016/j.tcb.2016.02.006 - DOI - PubMed - PMC
    1. Bilimoria PM, Stevens B (2015) Microglia function during brain development: new insights from animal models. Brain Res 1617:7–17. https://doi.org/10.1016/j.brainres.2014.11.032 - DOI - PubMed
    1. Paolicelli RC, Bolasco G, Pagani F, Maggi L, Scianni M, Panzanelli P et al (2011) Synaptic pruning by microglia is necessary for normal brain development. Science 333(6048):1456–1458. https://doi.org/10.1126/science.1202529 - DOI - PubMed

LinkOut - more resources