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Comment
. 2022 Jun 8;14(648):eabq7374.
doi: 10.1126/scitranslmed.abq7374. Epub 2022 Jun 8.

A step forward for LRRK2 inhibitors in Parkinson's disease

Patrick A Lewis  1   2   3
Affiliations
Comment

A step forward for LRRK2 inhibitors in Parkinson's disease

Patrick A Lewis. Sci Transl Med. .

Abstract

A phase 1 clinical trial for kinase inhibitors targeting LRRK2 provides the foundation for testing the efficacy of LRRK2 kinase inhibitors in Parkinson's disease.

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Comment on

  • Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease.
    Jennings D, Huntwork-Rodriguez S, Henry AG, Sasaki JC, Meisner R, Diaz D, Solanoy H, Wang X, Negrou E, Bondar VV, Ghosh R, Maloney MT, Propson NE, Zhu Y, Maciuca RD, Harris L, Kay A, LeWitt P, King TA, Kern D, Ellenbogen A, Goodman I, Siderowf A, Aldred J, Omidvar O, Masoud ST, Davis SS, Arguello A, Estrada AA, de Vicente J, Sweeney ZK, Astarita G, Borin MT, Wong BK, Wong H, Nguyen H, Scearce-Levie K, Ho C, Troyer MD. Jennings D, et al. Sci Transl Med. 2022 Jun 8;14(648):eabj2658. doi: 10.1126/scitranslmed.abj2658. Epub 2022 Jun 8. Sci Transl Med. 2022. PMID: 35675433

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