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Review
. 2022 Aug:69:102161.
doi: 10.1016/j.cbpa.2022.102161. Epub 2022 Jun 5.

Advanced functional fluorescent probes for cell plasma membranes

Mayeul Collot  1 , Sonia Pfister  2 , Andrey S Klymchenko  3
Affiliations
Review

Advanced functional fluorescent probes for cell plasma membranes

Mayeul Collot et al. Curr Opin Chem Biol. 2022 Aug.

Abstract

Imaging the plasma membrane (PM) by fluorescence techniques using molecular fluorescent probes enable cell segmentation, studying membrane organization and dynamics, formation, and tracking of vesicles. Rational molecular design brings fluorescent PM probes to a new level, providing PM probes with new functions beyond basic PM staining and imaging. We herein review the latest advances in fluorescent PM probes for chemical and biophysical sensing as well as for super-resolution imaging.

Keywords: Fluorescence microscopy; Fluorescent probes; Lipid probes; Plasma membrane probes; Probing cell surface; SMLM; STED; Super resolution.

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Conflict of interest statement

Declaration of competing interest The authors declare competing interests as the following fluorescent probes are commercialized by Cytoskeleton Inc.: MemBright series [7], NR12S, NR12A and NR4A, [32].

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