Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Apr;72(4):804-805.
doi: 10.1136/gutjnl-2022-327724. Epub 2022 Jun 8.

Maternal antibiotic exposure during pregnancy and risk of IBD in offspring: a population-based cohort study

Manasi Agrawal  1   2 , Gry Poulsen  3 , Jean-Frederic Colombel  2 , Kristine Højgaard Allin  3 , Tine Jess  3
Affiliations
Comment

Maternal antibiotic exposure during pregnancy and risk of IBD in offspring: a population-based cohort study

Manasi Agrawal et al. Gut. 2023 Apr.
No abstract available

Keywords: ANTIBIOTICS; CROHN'S DISEASE; EPIDEMIOLOGY; INFLAMMATORY BOWEL DISEASE; ULCERATIVE COLITIS.

PubMed Disclaimer

Conflict of interest statement

Competing interests: MA reports no conflict of interest. GP reports no conflict of interest. J-FC reports receiving research grants from AbbVie, Janssen Pharmaceuticals and Takeda; receiving payment for lectures from AbbVie, Amgen, Allergan, Ferring Pharmaceuticals, Shire and Takeda; receiving consulting fees from AbbVie, Amgen, Arena Pharmaceuticals, Boehringer Ingelheim, Bristol Myers Squibb, Celgene Corporation, Eli Lilly, Ferring Pharmaceuticals, Galmed Research, Glaxo Smith Kline, Geneva, Iterative Scopes, Janssen Pharmaceuticals, Kaleido Biosciences, Landos, Otsuka, Pfizer, Prometheus, Sanofi, Takeda and TiGenix; and hold stock options in Intestinal Biotech Development. KHA reports no conflict of interest. TJ reports no conflict of interest.

Figures

Figure:
Figure:. Forest plot reporting the association between cumulative antibiotic exposure during pregnancy and offspring risk of inflammatory bowel disease, ulcerative colitis and Crohn’s disease.
Abbreviations: IBD: inflammatory bowel disease; IR: incidence rate; PY: person years; HR: hazard ratio; CI: confidence interval *adjusted for calendar year of delivery, offspring gender, maternal age, maternal IBD diagnosis, maternal country of birth, municipality socioeconomic status and urbanization. In a sensitivity analysis, additional adjustment for maternal immune-mediated diseases or smoking resulted in similar estimates.
See this image and copyright information in PMC

Comment on

References

    1. Dierikx T, Berkhout D, Eck A, et al. Influence of timing of maternal antibiotic administration during caesarean section on infant microbial colonisation: a randomised controlled trial. Gut 2021. - PMC - PubMed
    1. Agrawal M, Sabino J, Frias-Gomes C, et al. Early life exposures and the risk of inflammatory bowel disease: Systematic review and meta-analyses. EClinicalMedicine 2021. - PMC - PubMed
    1. Vich Vila A, Imhann F, Collij V, et al. Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome. Sci Transl Med 2018;10. - PubMed
    1. Bernstein CN, Burchill C, Targownik LE, et al. Maternal Infections That Would Warrant Antibiotic Use Antepartum or Peripartum Are Not a Risk Factor for the Development of IBD: A Population-Based Analysis. Inflammatory Bowel Diseases 2017;23:635–640. - PubMed
    1. Ortqvist AK, Lundholm C, Halfvarson J, et al. Fetal and early life antibiotics exposure and very early onset inflammatory bowel disease: A population-based study. Gut 2019;68:218–225. - PubMed