PeSTK db a comprehensive data repository of Probiotic Serine Threonine kinases
- PMID: 35676297
- PMCID: PMC9178022
- DOI: 10.1038/s41597-022-01379-2
PeSTK db a comprehensive data repository of Probiotic Serine Threonine kinases
Abstract
The signal transduction pathway of prokaryotes involves a peptidoglycan synthesis cluster (PG) to sense external stimuli. One of the major components of the PG synthesis cluster is protein kinases (pknA - G). The sequence data of probiotic eSTKs (Eukaryotic like Serine, Threonine kinases) are obscure, scarce and essentially required to understand the role of probiotic microbes in combating infectious diseases. The most essential need to understand and develop certain therapeutic drugs against pathogens is the eSTK sequence data. Hence, we developed a comprehensive user-friendly data repository of probiotic eSTK's (PeSTK), which holds 830 STK sequences. Therefore, the data resource of PeSTK developed is unique, an open-access very summative containing various probiotic eSTK's in a single locality. The sequence datasets of the eSTK developed with easy-to-operate browsing as well as searching. Therefore, eSTK data resources should be useful for sequence-based studies and drug development. The sequence datasets are available at Figshare Digital Object Identifier/DOI of the sequences is https://doi.org/10.6084/m9.figshare.146606 .
© 2022. The Author(s).
Conflict of interest statement
The authors declare no competing interests.
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References
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- Alekseeva MG, Mavletova DA, Kolchina NV, Nezametdinova VZ, Denilenk VN. Isolation and Purification of Recombinant Serine/Threonine Protein Kinases of the strain Bifidobacterium longum B379M and investigation of their activity. Biochem. (Moscow) 2015;80:1303–1311. doi: 10.1134/S0006297915100119. - DOI - PubMed
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