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Clinical Trial
. 1978 Aug;37(4):351-6.
doi: 10.1136/ard.37.4.351.

Intra-articular methotrexate. Clinical and laboratory study in rheumatoid and psoriatic arthritis

G H Hall, B J Jones, A C Head, V E Jones
Clinical Trial

Intra-articular methotrexate. Clinical and laboratory study in rheumatoid and psoriatic arthritis

G H Hall et al. Ann Rheum Dis. 1978 Aug.

Abstract

The effects of intra-articular methotrexate (MTX) were compared with saline in 20 patients with persistent knee effusions due to rheumatoid arthritis (15) and psoriasis (5) in a double-blind pilot study. Clinical improvement was seen in most patients given either MTX or saline and was attributed to joint irrigation during arthroscopy and the placebo effects. MTX had a local anti-inflammatory effect in the psoriatic arthropathies; the percentages of polymorphonuclear cells and pyroninophilic mononuclear cells in synovial fluids fell sharply. Intraarticular hydrocortisone acetate was not anti-inflammatory in 2 psoriatic patients treated subsequently. The anti-inflammatory action of MTX in joints may resemble its effectiveness in controlling the rash of psoriasis.

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References

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