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Comment
. 2022 Jun;606(7913):E1-E3.
doi: 10.1038/s41586-022-04693-2. Epub 2022 Jun 8.

Limitations of gamete sequencing for crossover analysis

Carl Veller  1   2 , Shunxin Wang  3 , Denise Zickler  4 , Liangran Zhang  3   5   6 , Nancy Kleckner  7
Affiliations
Comment

Limitations of gamete sequencing for crossover analysis

Carl Veller et al. Nature. 2022 Jun.
No abstract available

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Conflict of interest statement

Competing interests The authors declare no competing interests.

Figures

Fig. 1 |
Fig. 1 |. Transmission of crossover crowding from bivalent chromosomes to two-crossover gametic chromosomes.
a, Crossover interference spaces crossovers (COs) evenly along bivalent chromosome axes, according to an approximately constant physical (micrometre) distance. Thus, for the same genetic chromosome, a longer chromosome axis (left) permits more crossovers than a shorter axis (right). b, As the chromosome has a constant megabase length, if crossover positions along the bivalent are analysed according to a megabase metric, they will be more crowded when the axis is physically longer (left) versus shorter (right). c–f, Two-crossover gametic chromosomes that arise from these bivalents (c; as depicted in f) will exhibit the effects of bivalent crossover crowding: when there was more crowding along the bivalent, the two gametic crossovers will, on average, be more centrally distributed (d) and more closely spaced (in megabases) (e). Thus, differential crossover crowding along bivalents can generate, qualitatively, the observations of Bell et al. g, Distribution of crossover positions along bivalents of chromosome 8 in a man with a high number of crossovers and a man with a low number of crossovers. Chromosome axis lengths are normalized to be equal, so that inter-crossover distances can be interpreted in megabases. Two-crossover gametic chromosomes sampled from the bivalents will more often derive from three-crossover bivalents for the individual with a high number of crossovers than for the individual with a low number of crossovers, and will therefore, in the individual with a high number of crossovers, disproportionately show the effects of the greater crossover crowding present on three-crossover bivalents: closer spacing (in megabases) and a more central distribution of crossovers. Panel g is adapted, with permission, from ref..
See this image and copyright information in PMC

Comment on

References

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