Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jun 8;23(5):161.
doi: 10.1208/s12249-022-02313-w.

Ionic Liquids Assisted Topical Drug Delivery for Permeation Enhancement: Formulation Strategies, Biomedical Applications, and Toxicological Perspective

Prerana D Navti  1 , Abhijeet Pandey  1 , Ajinkya Nitin Nikam  1 , Bharath Singh Padya  1 , Guruprasad Kalthur  2 , Kunnatur B Koteshwara  1 , Srinivas Mutalik  3
Affiliations
Review

Ionic Liquids Assisted Topical Drug Delivery for Permeation Enhancement: Formulation Strategies, Biomedical Applications, and Toxicological Perspective

Prerana D Navti et al. AAPS PharmSciTech. .

Abstract

Topical drug delivery provides several benefits over other conventional routes by providing localizing therapeutic effects and also avoids the gastrointestinal tract circumventing the first-pass metabolism and enzymatic drug degradation. Being painless, the topical route also prevents the difficulties linked with the parenteral route. However, there are limitations to the current topical systems which necessitate the need for further research to find functional excipients to overcome these limitations. This review deals in depth with the ionic liquids concerning their physicochemical properties and applicability as well as their role in the arena of topical drug delivery in permeation enhancement, bioavailability enhancement of the drugs by solvation, and drug moiety modification. The review gives a detailed insight into the recent literature on ionic liquid-based topical formulations like ionic liquid-based emulsions, active pharmaceutical ingredient-ionic liquids, ionic liquid-based bacterial cellulose membranes, topical small interfering RNA (siRNA) delivery, and ionogels as a possible solutions for overcoming the challenges associated with the topical route. This review also takes into account the toxicological aspects and biomedical applications of ionic liquids.

Keywords: biomedical applications; ionic liquids; permeation; skin; topical delivery; toxicological aspects.

PubMed Disclaimer

References

    1. Caparica R. Applicability of ionic liquids in topical drug delivery systems: a mini review. JPCR [Internet]. 2017 [cited 2020 Sep 10];4. Available from: https://juniperpublishers.com/jpcr/JPCR.MS.ID.555649.php
    1. Manikkath J, Sumathy T, Manikkath A, Mutalik S. Delving deeper into dermal and transdermal drug delivery: factors and mechanisms associated with nanocarrier-mediated strategies. CPD [Internet]. 2018 [cited 2021 Dec 26];24:3210–22. Available from: https://www.eurekaselect.com/165595/article
    1. Amaral M, Pereiro AB, Gaspar MM, Reis CP. Recent advances in ionic liquids and nanotechnology for drug delivery. Nanomedicine [Internet]. 2021 [cited 2021 Sep 18];16:63–80. Available from: https://www.futuremedicine.com/doi/10.2217/nnm-2020-0340
    1. Mutalik S, Shetty PK, Kumar A, Kalra R, Parekh HS. Enhancement in deposition and permeation of 5-fluorouracil through human epidermis assisted by peptide dendrimers. Drug Delivery [Internet]. 2014 [cited 2021 Dec 26];21:44–54. Available from: http://www.tandfonline.com/doi/full/10.3109/10717544.2013.845861
    1. Goindi S, Arora P, Kumar N, Puri A. Development of novel ionic liquid-based microemulsion formulation for dermal delivery of 5-fluorouracil. AAPS PharmSciTech [Internet]. 2014 [cited 2020 Aug 28];15:810–21. Available from: http://link.springer.com/10.1208/s12249-014-0103-1

LinkOut - more resources