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. 2022 Jun 8;22(1):631.
doi: 10.1186/s12885-022-09733-8.

Clinical determinants of recurrence in pTa bladder cancer following transurethral resection of bladder tumor

Seung-Hwan Jeong  1 , Jang Hee Han  1 , Chang Wook Jeong  1   2 , Hyeon Hoe Kim  1   2 , Cheol Kwak  1   2 , Hyeong Dong Yuk  3   4 , Ja Hyeon Ku  5   6
Affiliations

Clinical determinants of recurrence in pTa bladder cancer following transurethral resection of bladder tumor

Seung-Hwan Jeong et al. BMC Cancer. .

Abstract

Background: Non-muscle invasive bladder cancer can be controlled by transurethral resection of bladder (TURB), but suffers from frequent recurrences in 60-70% of cases. Although, recurrence interval after TURB influences treatment course and prognosis, its implication and risk factors have not been fully elucidated. We evaluated the risk factors of early (within 1 yr) and late (after 1 yr) recurrence of pTa bladder cancer and clinical significance of recurrence interval on disease progression and overall survival.

Methods: In this study, pTa bladder cancer patients enrolled in prospective patient registry system of Seoul National University, SUPER-UC, were retrospectively examined to determine the clinical risk factors for recurrence and its significance regarding to recurrence interval. A total of 1067 bladder cancer patients who underwent TURB between March 20 and June 2021 were included and classified into three groups of no recurrence, early, or late recurrence to be comparatively analyzed.

Results: Early recurrence was associated with poorer cystectomy-free survival and overall survival than late recurrence. Risk factors for early recurrence included a high number of previous TURB, tumor multiplicity, tumor location, tumor shape, incompleteness of TURB, and high tumor grade. Otherwise, late recurrence was associated with low-grade tumors with insufficient TURB depth.

Conclusion: Patients with risk factors for early recurrence should be closely followed up with special cautions.

Keywords: Recurrence; TURB; Ta bladder cancer.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Fig. 1
Fig. 1
Cystectomy-free and Overall survival in early and late recurrence patients. Red and green lines represent early and late recurrence respectively
See this image and copyright information in PMC

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