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Case Reports
. 2022 May 7;14(5):e24802.
doi: 10.7759/cureus.24802. eCollection 2022 May.

A Rare Case of Myocarditis After the First Dose of Moderna Vaccine in a Patient With Two Previous COVID-19 Infections

Aniekeme S Etuk  1 , Inimfon N Jackson  2 , Hercules Panayiotou  3
Affiliations
Case Reports

A Rare Case of Myocarditis After the First Dose of Moderna Vaccine in a Patient With Two Previous COVID-19 Infections

Aniekeme S Etuk et al. Cureus. .

Abstract

Myocarditis is the inflammation of the cardiac muscle caused by a variety of factors ranging from infections to autoimmune diseases. Most cases of vaccine-induced myocarditis occur after the second dose of vaccination; however, a few cases have been reported following the first dose of vaccination with or without previous coronavirus disease 2019 (COVID-19) infection. A case of myocarditis occurring about three weeks after the first dose of the Moderna vaccine has been reported in a patient with one previous COVID-19 infection. However, there have not been any documented cases of myocarditis after the first dose of the Moderna vaccine in a patient with two prior COVID-19 infections. Our index patient had already experienced two COVID-19 infections in the past and was diagnosed with myocarditis eight hours after receiving the first dose of the Moderna vaccine. The susceptibility to developing this likely stems from the possible production of antibodies to the viral antigen from previous COVID-19 infections. Furthermore, the fact that our patient developed symptoms eight hours after receiving the vaccine suggests a possible additive effect of antibodies produced from the two previous COVID-19 infections. This case report suggests that individuals repeatedly infected with COVID-19 may be at increased risk of myocarditis following the administration of the Moderna vaccine.

Keywords: antibodies; antigen; covid-19 infection; moderna vaccine; post vaccination myocarditis.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. EKG showing normal sinus rhythm with ST-segment elevation in some lateral leads (I and aVL)
EKG: electrocardiogram
Figure 2
Figure 2. Cardiac MRI
The image shows patchy mural delayed myocardial enhancement with relative sparing of the endocardium within the septum, and inferior and lateral walls at the cardiac base MRI: magnetic resonance imaging
See this image and copyright information in PMC

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