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Review
. 2022 May 5;14(5):e24749.
doi: 10.7759/cureus.24749. eCollection 2022 May.

Anti-candidal Effect of Ocimum sanctum: A Systematic Review on Microbial Studies

Chandini R  1 , Saranya R  1 , Khadijah Mohideen  1 , Preethi Nandagopal  2 , Logeswari Jayamani  3 , Sreedevi Jeyakumaran  4
Affiliations
Review

Anti-candidal Effect of Ocimum sanctum: A Systematic Review on Microbial Studies

Chandini R et al. Cureus. .

Abstract

Candida albicans is the most prevalent candidal species in humans. It is the causative agent and is most commonly associated with more than 90% of serious systemic fungal infections. Even though there are numerous anti-fungal agents, new strains of pathogens develop resistance against these agents. In order to prevent resistance, plant-based drugs can be considered as an alternative therapy. Recent studies show that few herbs consist of active ingredients acting against specific pathogens. The aim of the present study is to understand the anti-candidal effect of Ocimum sanctum (Tulsi) based on in-vitro microbial studies. This systematic review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement Criteria (PRISMA). Articles were collected from the electronic databases of PubMed and Cochrane till 2021. Anti-microbial studies on O. sanctum and its action against candidal species were included. We excluded clinical trials, reviews, abstract articles, and interventional studies. The selected antimicrobial studies used various phytochemical constituents of Tulsi extract, and the anticandidal properties were measured through the zone of inhibition (ZOI). All studies demonstrated the effective anticandidal property of O. sanctum, suggesting its possible use as an effective and affordable "adjunct" along with standard care for systemic and topical candidal infections. The main components of O. sanctum responsible for anticandidal activity were likely to be eugenol and linalool. However, the mechanism of action of these constituents is unclear. Further research assessing the toxicity, durability, and other assessments followed by clinical trials is necessary to explore the potential of Tulsi in combating oral conditions.

Keywords: anticandidal effect; antifungal resistance; candida species. antifungal susceptibility. minimum inhibitory concentration; invitro; ocimum sanctum.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. PRISMA protocol - systematic review for included articles
See this image and copyright information in PMC

References

    1. Opportunistic invasive fungal infections: diagnosis & clinical management. Badiee P, Hashemizadeh Z. https://pubmed.ncbi.nlm.nih.gov/24718393/ Indian J Med Res. 2014;139:195–204. - PMC - PubMed
    1. Candida parapsilosis, an emerging fungal pathogen. Trofa D, Gácser A, Nosanchuk JD. Clin Microbiol Rev. 2008;21:606–625. - PMC - PubMed
    1. The Candida pathogenic species complex. Turner SA, Butler G. Cold Spring Harb Perspect Med. 2014;4:0. - PMC - PubMed
    1. Development of botanicals to combat antibiotic resistance. Gupta PD, Birdi TJ. J Ayurveda Integr Med. 2017;8:266–275. - PMC - PubMed
    1. Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review. Prakash P, Gupta N. https://pubmed.ncbi.nlm.nih.gov/16170979/ Indian J Physiol Pharmacol. 2005;49:125–131. - PubMed

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