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Review
. 2022 May 23:13:824420.
doi: 10.3389/fphar.2022.824420. eCollection 2022.

Current Evidence and Future Directions of Berberine Intervention in Depression

Wen-Qian Zhu  1 , Hui-Ying Wu  1 , Zhi-Hui Sun  2 , Yi Guo  3 , Tong-Tong Ge  1 , Bing-Jin Li  1 , Xin Li  1 , Ran-Ji Cui  1
Affiliations
Review

Current Evidence and Future Directions of Berberine Intervention in Depression

Wen-Qian Zhu et al. Front Pharmacol. .

Abstract

A major type of serious mood disorder, depression is currently a widespread and easily overlooked psychological illness. With the low side effects of natural products in the treatment of diseases becoming the pursuit of new antidepressants, natural Chinese medicine products have been paid more and more attention for their unique efficacy in improving depression. In a view from the current study, the positive antidepressant effects of berberine are encouraging. There is a lot of work that needs to be done to accurately elucidate the efficacy and mechanism of berberine in depression. In this review, the relevant literature reports on the treatment of depression and anxiety by berberine are updated, and the potential pharmacological mechanism of berberine in relieving depression has also been discussed.

Keywords: berberine; bioamine; depression; natural active ingredients; neuroplasticity.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Chemical structural formula of berberine, associated depression models, and clinical diseases.
See this image and copyright information in PMC

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References

    1. Azam S., Jakaria M., Kim I. S., Kim J., Haque M. E., Choi D. K. (2019). Regulation of Toll-like Receptor (TLR) Signaling Pathway by Polyphenols in the Treatment of Age-Linked Neurodegenerative Diseases: Focus on TLR4 Signaling. Front. Immunol. 10, 1000. 10.3389/fimmu.2019.01000 - DOI - PMC - PubMed
    1. Banerjee A., Singh S., Prasad S. K., Kumar S., Banerjee O., Seal T., et al. (2020). Protective Efficacy of Tinospora Sinensis against Streptozotocin Induced Pancreatic Islet Cell Injuries of Diabetic Rats and its Correlation to its Phytochemical Profiles. J. Ethnopharmacol. 248, 112356. 10.1016/j.jep.2019.112356 - DOI - PubMed
    1. Camuso S., La Rosa P., Fiorenza M. T., Canterini S. (2021). Pleiotropic Effects of BDNF on the Cerebellum and hippocampus: Implications for Neurodevelopmental Disorders. Neurobiol. Dis. 163, 105606. 10.1016/j.nbd.2021.105606 - DOI - PubMed
    1. Chen X., Chen Y., Qi D., Cui D. (2022). Multifaceted Interconnections between Macrophage Migration Inhibitory Factor and Psychiatric Disorders. Prog. Neuropsychopharmacol. Biol. Psychiatry 112, 110422. 10.1016/j.pnpbp.2021.110422 - DOI - PubMed
    1. Chouinard G., Chouinard V. A. (2015). New Classification of Selective Serotonin Reuptake Inhibitor Withdrawal. Psychother. Psychosom. 84, 63–71. 10.1159/000371865 - DOI - PubMed

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