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Review
. 2022 Jun 6:2022:8508489.
doi: 10.1155/2022/8508489. eCollection 2022.

Effect of Preexisting Asthma on the Risk of ICU Admission, Intubation, and Death from COVID-19: A Systematic Review and Meta-Analysis

Abhinav Bhattarai  1 , Garima Dhakal  1 , Sangam Shah  1 , Aastha Subedi  2 , Sanjit Kumar Sah  3 , Shyam Kumar Mishra  4
Affiliations
Review

Effect of Preexisting Asthma on the Risk of ICU Admission, Intubation, and Death from COVID-19: A Systematic Review and Meta-Analysis

Abhinav Bhattarai et al. Interdiscip Perspect Infect Dis. .

Abstract

Background: The Centers for Disease Control and Prevention (CDC) identifies asthma as a comorbidity in COVID-19 that increases the risk of severity and death. However, research has shown that asthma is not associated with increased severity and death, thus making the consequences of asthma in COVID-19 unclear.

Methods: We searched the electronic databases PubMed, WHO COVID-19 database, and Taylor and Francis Online for studies that compared the medical outcomes of COVID-19 between patients with and without asthma, from the emergence of SARS-CoV-2 in December 2019 to the 3rd of September 2021, excluded duplicates, reviews, editorials, and case reports, and screened the titles, abstracts, and full texts. The quality of the included studies was assessed using the Newcastle-Ottawa Scale (NOS) for nonrandomized studies. Rates of intensive care unit (ICU) admission, intubation, and death among patients with and without asthma were compiled and meta-analysis was conducted using a random-effects model.

Results: Nineteen studies with a total of 289,449 participants met the inclusion criteria. COVID-19 patients with asthma had no significant association with increased risk of ICU admission, intubation, and death as compared with those without asthma ((odds ratio (OR) = 1.25, confidence interval (CI) = 0.90-1.74, I 2 = 82%, X 2 = 55.13, p < 0.01), (OR = 0.89, CI = 0.59-1.34, I 2 = 91%, X 2 = 110.82, p < 0.01), and (OR = 0.90, 95% CI = 0.63-1.27, I 2 = 88%, X 2 = 146.96, p < 0.01)), respectively.

Conclusion: Preexisting asthma did not significantly increase the risk of poorer prognosis and death from COVID-19.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram.
Figure 2
Figure 2
Quality assessment of studies.
Figure 3
Figure 3
Forest plot showing the risk of ICU admission.
Figure 4
Figure 4
Forest plot showing risk of intubation.
Figure 5
Figure 5
Forest plot showing the risk of mortality.
See this image and copyright information in PMC

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References

    1. COVID live update: 264,557,547 cases and 5,252,454 deaths from the Coronavirus—worldometer, https://www.worldometers.info/coronavirus/
    1. People with certain medical conditions, https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/people-....
    1. Asthma and COVID-19 scientific brief 19, https://www.cebm.net/covid-19/risks-of-and-from-sars-cov-2-covid-19-infe...
    1. Skappak C., Ilarraza R., Wu Y. Q., Drake M. G., Adamko D. J. Virus-induced Asthma attack: The importance of allergic inflammation in response to viral antigen in an animal model of Asthma. PLoS One . 2017;12e0181425 - PMC - PubMed
    1. Parasher A. COVID-19: current understanding of its pathophysiology, clinical presentation and treatment. Postgraduate Medical Journal . 2021;97 - PMC - PubMed

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