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Observational Study
. 2022 Oct 1;50(10):1486-1493.
doi: 10.1097/CCM.0000000000005593. Epub 2022 Sep 12.

Right-to-Left Shunts Occur During Cardiopulmonary Resuscitation: Echocardiographic Observations

Woo Jin Jung  1 , Kyoung-Chul Cha  1 , Young-Il Roh  1 , Kyung Soo Bae  1 , Tae Hyun Kwon  1 , Jae Hun Han  2 , Sung Oh Hwang  1
Affiliations
Observational Study

Right-to-Left Shunts Occur During Cardiopulmonary Resuscitation: Echocardiographic Observations

Woo Jin Jung et al. Crit Care Med. .

Abstract

Objectives: A significant proportion of the population has a patent foramen ovale (PFO). The intracardiac pressure during cardiopulmonary resuscitation (CPR) may differ from that of normal circulation, which may result in a right-to-left shunt in the presence of a PFO. In this study, transesophageal echocardiography (TEE) was conducted to evaluate whether CPR carried out in patients after cardiac arrest causes right-to-left shunt.

Design: A retrospective observational study.

Setting: One academic medical center from January 2017 to April 2020.

Patients: Patients older than 20 years who suffered from nontraumatic out-of-hospital cardiac arrest (OHCA) and underwent intra-arrest TEE.

Measurement and main results: Patients who had microbubbles resulting from fluid injection in the right atrium, as indicated on TEE imaging, were included in the analysis. The presence of right-to-left shunt was defined as the appearance of microbubbles in the systemic circulation, including the left atrium, left ventricle, or aorta. A total of 97 patients were included in the final analysis. A right-to-left shunt was observed in 21 patients (21.6%), and no shunt was found in 76 patients (78.4%). The degree of the right-to-left shunt, determined by the number of microbubbles, was mild in 11 patients (52.4%), moderate in eight (38.0%), and severe in two (9.6%). Multivariate analysis showed that no factors were associated with the presence of right-to-left shunt during CPR.

Conclusions: Right-to-left shunts can be appreciated during CPR in patients who experience OHCA. Further studies are needed to verify its clinical significance.

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Conflict of interest statement

Drs. Bae, Kwon, and Han disclosed work for hire. The remaining authors have disclosed that they do not have any potential conflicts of interest.

References

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