Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2022 Jun 9;17(6):e0265930.
doi: 10.1371/journal.pone.0265930. eCollection 2022.

Chronic kidney disease in cancer patients, the analysis of a large oncology database from Eastern Europe

Mircea Ciorcan  1   2 , Lazar Chisavu  3   4   5 , Adelina Mihaescu  3   4 , Florica Gadalean  3   4 , Flaviu Raul Bob  3   4 , Serban Negru  6 , Oana Marina Schiller  7 , Iulia Dana Grosu  3   4 , Luciana Marc  3   4 , Flavia Chisavu  8 , Razvan Dragota Pascota  9 , Adrian Apostol  4   10 , Viviana Ivan  4   5   11 , Adalbert Schiller  3   4
Affiliations
Observational Study

Chronic kidney disease in cancer patients, the analysis of a large oncology database from Eastern Europe

Mircea Ciorcan et al. PLoS One. .

Abstract

Introduction: Kidney dysfunction is prevalent in oncology patients and has an impact on their treatment and quality of life. The aim of our study was to analyze the prevalence of CKD in a large cohort of several types of cancer patients in an East European Region.

Material and methods: We conducted an observational retrospective cohort study on 5831 consecutive, biopsy-diagnosed cancer patients between January 2019 -December 2020 in the largest oncology hospital and outpatient clinic in Western Romania. 4342 subjects were included in the statistical analysis.

Results and discussion: From the 24 cancer types, the most prevalent cancers were represented by: breast (22.02%), lung (10.18%) and colonic cancer (9.51%). The prevalence of CKD (G3 -G5) was 12.27% after the first year of follow-up and 13.42 after the second year. The prevalence of CKD was higher in patients with renal (50%), urinary tract (33.6%) and pancreatic cancers (19.6%) and lower in patients with colonic cancers (5.3%) and brain tumors (2.5%). At the end of our 2-year survey period, 0,7% of the CKD cases had an eGFR around 6 ml/min/1.73m2 -an indication for renal replacement therapy.

Conclusion: Oncology patients have a significantly higher prevalence of CKD compared to the general population, dependent of the age of the patients and the type of cancer. The prevalence of advanced CKD was surprisingly high (stages G4-G5 Pre-Dialysis 22.15%) one third of the CKD- G5 patients having indication for initiation of renal replacement therapy. An onco- nephrology team should be needed for the best medical care of these patients.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. CKD prevalence and absolute number of CKD patients in different cancer types.
See this image and copyright information in PMC

References

    1. Rosner M.H., Jhaveri K.D, McMahon B.A., Perazella M.A. Onconephrology: The Intersections Between the Kidney and Cancer CA Cancer J Clin 2021;71:47–77. doi: 10.3322/caac.21636 - DOI - PubMed
    1. Perazella MA. Onco-nephrology: renal toxicities of chemotherapeutic agents. Clin J Am Soc Nephrol. 2012;7:1713–172. doi: 10.2215/CJN.02780312 - DOI - PubMed
    1. Porta C, Cosmai L, Gallieni M, Pedrazzoli P, Malberti F. Renal effects of targetedanticancer therapies. Nat Rev Nephrol. 2015;11:354–370. doi: 10.1038/nrneph.2015.15 - DOI - PubMed
    1. Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate [published correction appears in Ann Intern Med. 2011 Sep 20;155(6):408]. Ann Intern Med. 2009;150(9):604–612. doi: 10.7326/0003-4819-150-9-200905050-00006 - DOI - PMC - PubMed
    1. Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Update Work Group. KDIGO 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD). Kidney Int Suppl. 2017;7:1–59. - PMC - PubMed

Publication types