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Case Reports
. 1987 May;71(5):471-4.

Hexamethylene bisacetamide-induced cutaneous vasculitis

E K Rowinsky, W P McGuire, G J Anhalt, D S Ettinger, R C Donehower
  • PMID: 3567971
Case Reports

Hexamethylene bisacetamide-induced cutaneous vasculitis

E K Rowinsky et al. Cancer Treat Rep. 1987 May.

Abstract

Nonthrombocytopenic purpura developed in a patient receiving hexamethylene bisacetamide, a tumor-differentiating agent in vitro that is in phase I clinical trials. Histopathological examination revealed features of leukocytoclastic vasculitis with deposition of IgA and complement in the dermal vasculature. Leukocytoclastic vasculitis, an extremely rare complication of therapy with antineoplastic agents, is reported to alert others using this compound of this association.

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