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Review
. 2022 Jun 14;79(23):2349-2366.
doi: 10.1016/j.jacc.2022.03.379.

Inflammasome Signaling in Atrial Fibrillation: JACC State-of-the-Art Review

Amir Ajoolabady  1 , Stanley Nattel  2 , Gregory Y H Lip  3 , Jun Ren  4
Affiliations
Review

Inflammasome Signaling in Atrial Fibrillation: JACC State-of-the-Art Review

Amir Ajoolabady et al. J Am Coll Cardiol. .

Abstract

As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in patients with cardiovascular diseases. Despite the multifaceted nature of AF pathogenesis and complexity of AF pathophysiology, a growing body of evidence indicates that the NLRP3 inflammasome activation contributes to onset and progression of AF. Herein, the authors aim at reviewing the current literature on the role of inflammasome signaling in AF pathogenesis, and novel therapeutic options in the management of AF.

Keywords: NLRP3 inflammasome; atrial fibrillation; inflammation; interleukins.

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Conflict of interest statement

Funding Support and Author Disclosures Dr Nattel is supported by the Canadian Institutes of Health Research. Dr Lip has been a consultant and speaker for Bristol Myers Squibb/Pfizer, Boehringer Ingelheim, and Daiichi-Sankyo; no fees are received personally. Dr Ren has received support in part from the Natural Science Foundation of China (82130011). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

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