Delayed-type hypersensitivity reaction to St. John's wort extract confirmed by patch testing

Thomas O'Hagan¹, Ilaria Bisconti¹, Claire Leck¹, Thippeswamy Billahalli¹, Sheena Barnett^{1

2}, Karalasingam Rajakulasingam^{1

2}, Timothy J Watts^{1

3}

Affiliations

¹ Department of Respiratory Medicine & Allergy, Homerton Healthcare NHS Foundation Trust, London, UK.
² Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
³ National Heart & Lung Institute, Imperial College London, London, UK.

Case Reports

Thomas O'Hagan et al. Contact Dermatitis. 2022 Oct.

. 2022 Oct;87(4):381-383.

doi: 10.1111/cod.14172. Epub 2022 Jun 18.

Thomas O'Hagan¹, Ilaria Bisconti¹, Claire Leck¹, Thippeswamy Billahalli¹, Sheena Barnett^{1

2}, Karalasingam Rajakulasingam^{1

2}, Timothy J Watts^{1

3}

¹ Department of Respiratory Medicine & Allergy, Homerton Healthcare NHS Foundation Trust, London, UK.
² Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
³ National Heart & Lung Institute, Imperial College London, London, UK.

No abstract available

Keywords: St. John's wort; case report; delayed-type hypersensitivity; drug patch testing.

References

1. Apaydin EA, Maher AR, Shanman R, et al. A systematic review of St. John's wort for major depressive disorder. Syst Rev. 2016;5(1):148.
1. Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA. 2003;290(11):1500-1504.
1. Holme SA, Roberts DL. Erythroderma associated with St John's wort. Br J Dermatol. 2000;143(5):1127-1128.
1. Gangemi S, Minciullo PL, Miroddi M, Chinou I, Calapai G, Schmidt RJ. Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products - part 2: Echinacea purpurea-Lavandula angustifolia. Contact Dermatitis. 2015;72(4):193-205.
1. Farmer PW. The patch test as a means of diagnosis in contact dermatitis. Med J Aust. 1941;1:9-11.