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. 2022 Jun 4;12(11):1459.
doi: 10.3390/ani12111459.

First Description of Serological Evidence for SARS-CoV-2 in Lactating Cows

Filomena Fiorito  1 , Valentina Iovane  2 , Ugo Pagnini  1 , Claudia Cerracchio  1 , Sergio Brandi  3 , Martina Levante  3 , Luisa Marati  3 , Gianmarco Ferrara  1 , Virginio Tammaro  4 , Esterina De Carlo  3 , Giuseppe Iovane  1 , Giovanna Fusco  3
Affiliations

First Description of Serological Evidence for SARS-CoV-2 in Lactating Cows

Filomena Fiorito et al. Animals (Basel). .

Abstract

Following the COVID-19 epidemic outbreak in Ariano Irpino, Campania region (Italy), we tested lactating cows for the presence of SARS-CoV-2 on a cattle farm at which, prior to the investigation, 13 of the 20 farmworkers showed COVID-19-like symptoms, and one of them died. Twenty-four lactating cows were sampled to detect SARS-CoV-2. All nasal and rectal swabs and milk samples were negative for SARS-CoV-2 RNA. Of the 24 collected serum samples, 11 showed antibodies against SARS-CoV-2 nucleocapsid protein, 14 showed antibodies against SARS-CoV-2 spike protein, and 13 developed neutralising antibodies for SARS-COV-2; all samples were negative for Bovine Coronavirus (BCoV), another betacoronavirus. To our knowledge, this is the first report of natural serological evidence of SARS-CoV-2 infection in lactating cows. We hypothesise that this may be a case of reverse zoonosis. However, the role of cattle in SARS-CoV-2 infection and transmission seems to be negligible.

Keywords: COVID-19; SARS-CoV-2; cattle; farmworkers; reverse zoonosis; serology.

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Conflict of interest statement

The authors declare no conflict of interest.

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