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Review
. 2022 May 27;23(11):6022.
doi: 10.3390/ijms23116022.

An Insight into Recent Advances on Platelet Function in Health and Disease

Preeti Kumari Chaudhary  1 , Sanggu Kim  1 , Soochong Kim  1
Affiliations
Review

An Insight into Recent Advances on Platelet Function in Health and Disease

Preeti Kumari Chaudhary et al. Int J Mol Sci. .

Abstract

Platelets play a variety of roles in vascular biology and are best recognized as primary hemostasis and thrombosis mediators. Platelets have a large number of receptors and secretory molecules that are required for platelet functionality. Upon activation, platelets release multiple substances that have the ability to influence both physiological and pathophysiological processes including inflammation, tissue regeneration and repair, cancer progression, and spreading. The involvement of platelets in the progression and seriousness of a variety of disorders other than thrombosis is still being discovered, especially in the areas of inflammation and the immunological response. This review represents an integrated summary of recent advances on the function of platelets in pathophysiology that connects hemostasis, inflammation, and immunological response in health and disease and suggests that antiplatelet treatment might be used for more than only thrombosis.

Keywords: COVID-19; CVDs; cancer; diabetes mellitus; inflammation; platelet; wound healing.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Role of platelet in health and disease. Platelets are versatile cells engaged in numerous pathophysiological processes including inflammation and immunity, angiogenesis, regeneration, and carcinogenesis, in addition to their crucial role in thrombosis and hemostasis via various molecular and cellular events. This figure introduces the emerging role of platelets in the immune system, vascular biology, tumorigenesis, and beyond. VEGF, vascular endothelial growth factor; FGF, fibroblast growth factor; PDGF, platelet-derived growth factor; MMP, matrix metalloproteinase; EMT, epithelial-mesenchymal transition; PF4, platelet factor 4; RANTES, regulated upon activation, normal T cell expressed and presumably secreted; IL-1, interleukin 1; vWF, von Willebrand factor; ADP, Adenosine diphosphate. Created with BioRender.com. Available online: https://app.biorender.com/illustrations/626bc5c233d53778dbd97902 (accessed on 19 May 2022).
See this image and copyright information in PMC

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