Oral Fibrosis and Oral Cancer: From Molecular Targets to Therapeutics

doi:10.3390/ijms23116110

Editorial

. 2022 May 30;23(11):6110.

doi: 10.3390/ijms23116110.

Oral Fibrosis and Oral Cancer: From Molecular Targets to Therapeutics

Pei-Ling Hsieh¹, Cheng-Chia Yu^{2

3

4}

Affiliations

¹ Department of Anatomy, School of Medicine, China Medical University, Taichung 404333, Taiwan.
² School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan.
³ Department of Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
⁴ Institute of Oral Sciences, Chung Shan Medical University, Taichung 40201, Taiwan.

PMID: 35682789
PMCID: PMC9181066
DOI: 10.3390/ijms23116110

Editorial

Oral Fibrosis and Oral Cancer: From Molecular Targets to Therapeutics

Pei-Ling Hsieh et al. Int J Mol Sci. 2022.

. 2022 May 30;23(11):6110.

doi: 10.3390/ijms23116110.

Authors

Pei-Ling Hsieh¹, Cheng-Chia Yu^{2

3

4}

Affiliations

¹ Department of Anatomy, School of Medicine, China Medical University, Taichung 404333, Taiwan.
² School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan.
³ Department of Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
⁴ Institute of Oral Sciences, Chung Shan Medical University, Taichung 40201, Taiwan.

PMID: 35682789
PMCID: PMC9181066
DOI: 10.3390/ijms23116110

Abstract

Oral submucous fibrosis (OSF) belongs to a group of potentially malignant disorders that are characterized by the progressive fibrosis of the lining mucosa as well as an increasing loss of tissue mobility [...].

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Conflict of interest statement

The authors declare no conflict of interest.

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References

1. Dvorak H.F. Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 1986;315:1650–1659. - PubMed
1. Chen Y., Kim J., Yang S., Wang H., Wu C.-J., Sugimoto H., LeBleu V.S., Kalluri R. Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer. Cancer Cell. 2021;39:548–565.e546. doi: 10.1016/j.ccell.2021.02.007. - DOI - PMC - PubMed
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1. Lin C.-Y., Hsieh P.-L., Liao Y.-W., Peng C.-Y., Yu C.-C., Lu M.-Y. Arctigenin Reduces Myofibroblast Activities in Oral Submucous Fibrosis by LINC00974 Inhibition. Int. J. Mol. Sci. 2019;20:1328. doi: 10.3390/ijms20061328. - DOI - PMC - PubMed
1. Han B., Zhang Y., Xiao Y., Shi B., Wu H., Liu D. Adipose-Derived Stem Cell-Derived Extracellular Vesicles Inhibit the Fibrosis of Fibrotic Buccal Mucosal Fibroblasts via the MicroRNA-375/FOXF1 Axis. Stem Cells Int. 2021;2021:9964159. doi: 10.1155/2021/9964159. - DOI - PMC - PubMed

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[1] Dvorak H.F. Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 1986;315:1650–1659. - PubMed

[2] Dvorak H.F. Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 1986;315:1650–1659. - PubMed

[3] Chen Y., Kim J., Yang S., Wang H., Wu C.-J., Sugimoto H., LeBleu V.S., Kalluri R. Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer. Cancer Cell. 2021;39:548–565.e546. doi: 10.1016/j.ccell.2021.02.007. - DOI - PMC - PubMed

[4] Chen Y., Kim J., Yang S., Wang H., Wu C.-J., Sugimoto H., LeBleu V.S., Kalluri R. Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer. Cancer Cell. 2021;39:548–565.e546. doi: 10.1016/j.ccell.2021.02.007. - DOI - PMC - PubMed

[5] Sahai E., Astsaturov I., Cukierman E., DeNardo D.G., Egeblad M., Evans R.M., Fearon D., Greten F.R., Hingorani S.R., Hunter T., et al. A framework for advancing our understanding of cancer-associated fibroblasts. Nat. Rev. Cancer. 2020;20:174–186. doi: 10.1038/s41568-019-0238-1. - DOI - PMC - PubMed

[6] Sahai E., Astsaturov I., Cukierman E., DeNardo D.G., Egeblad M., Evans R.M., Fearon D., Greten F.R., Hingorani S.R., Hunter T., et al. A framework for advancing our understanding of cancer-associated fibroblasts. Nat. Rev. Cancer. 2020;20:174–186. doi: 10.1038/s41568-019-0238-1. - DOI - PMC - PubMed

[7] Lin C.-Y., Hsieh P.-L., Liao Y.-W., Peng C.-Y., Yu C.-C., Lu M.-Y. Arctigenin Reduces Myofibroblast Activities in Oral Submucous Fibrosis by LINC00974 Inhibition. Int. J. Mol. Sci. 2019;20:1328. doi: 10.3390/ijms20061328. - DOI - PMC - PubMed

[8] Lin C.-Y., Hsieh P.-L., Liao Y.-W., Peng C.-Y., Yu C.-C., Lu M.-Y. Arctigenin Reduces Myofibroblast Activities in Oral Submucous Fibrosis by LINC00974 Inhibition. Int. J. Mol. Sci. 2019;20:1328. doi: 10.3390/ijms20061328. - DOI - PMC - PubMed

[9] Han B., Zhang Y., Xiao Y., Shi B., Wu H., Liu D. Adipose-Derived Stem Cell-Derived Extracellular Vesicles Inhibit the Fibrosis of Fibrotic Buccal Mucosal Fibroblasts via the MicroRNA-375/FOXF1 Axis. Stem Cells Int. 2021;2021:9964159. doi: 10.1155/2021/9964159. - DOI - PMC - PubMed

[10] Han B., Zhang Y., Xiao Y., Shi B., Wu H., Liu D. Adipose-Derived Stem Cell-Derived Extracellular Vesicles Inhibit the Fibrosis of Fibrotic Buccal Mucosal Fibroblasts via the MicroRNA-375/FOXF1 Axis. Stem Cells Int. 2021;2021:9964159. doi: 10.1155/2021/9964159. - DOI - PMC - PubMed

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Oral Fibrosis and Oral Cancer: From Molecular Targets to Therapeutics

Affiliations

Oral Fibrosis and Oral Cancer: From Molecular Targets to Therapeutics

Authors

Affiliations

Abstract

Conflict of interest statement

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Abstract

Conflict of interest statement

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