Hypertriglyceridemia and Other Risk Factors of Chronic Kidney Disease in Type 2 Diabetes: A Hospital-Based Clinic Population in Greece

Abstract

Aims/introduction: Several reports indicate an increasing prevalence of chronic kidney disease (CKD) in type 2 diabetes mellitus (T2DM). Hyperglycemia and hypertension are the main risk factors for CKD development and progression. However, despite the achievement of recommended targets for blood glucose and blood pressure (BP), the residual risk of diabetic chronic kidney disease (DCKD) remains relatively high. The aim of this study is to examine dyslipidemia and other major risk factors to provide support for the prevention and treatment of DCKD.

Materials and methods: Participants are from the Redit-2-Diag study that examines 1759 subjects within a period of 6 months. DCKD severity is staged according to KDIGO criteria.

Results: An increase in hemoglobin A_1c (1 unit) and systolic blood pressure (1 mm Hg) increases the probability of being classified into a higher CKD stage by 14% and 26%, respectively. Moreover, an increase of triglycerides by 88.5 mg/dL increases the risk of classification to a worse CKD stage by 24%.

Conclusions: Elevated triglycerides, systolic blood pressure, and poor glycemic control increase the risk of CKD in T2DM and should be addressed in the treatment strategies.

Keywords: blood pressure; diabetic chronic kidney disease; triglycerides; type 2 diabetes mellitus.

Figure 1

Plasma concentrations of lipid levels in subjects with T2DM and normal kidney function (NKF) or diabetic chronic kidney disease (DCKD). * p < 0.01.

Figure 2

An increase of HbA_1c by 1 unit, triglycerides (TG) by 88.5 mg/dL, and systolic blood pressure (SBP) by 1 mm Hg, increased the progression of diabetic chronic kidney disease (DCKD) by 14%, 24%, and 26%, respectively.