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. 2022 Jun 6;11(11):3240.
doi: 10.3390/jcm11113240.

Quality of Life in the First Year after Ischemic Stroke Treated with Acute Revascularization Therapy

Aboudou Matinou Do Rego  1   2 , Gauthier Duloquin  2   3 , Marie Sauvant  2   3 , Simon Amaral  2   3 , Quentin Thomas  2   3 , Hervé Devilliers  1   4 , Yannick Béjot  2   3
Affiliations

Quality of Life in the First Year after Ischemic Stroke Treated with Acute Revascularization Therapy

Aboudou Matinou Do Rego et al. J Clin Med. .

Abstract

(1) Background: we aimed to describe the disease-specific quality of life (QoL) of ischemic stroke patients treated with acute revascularization therapy, its evolution from 6 months to 12 months, and associated factors. (2) Methods: QoL was assessed with the SS-QoL in consecutive patients treated with either intravenous thrombolysis (IVT) and/or mechanical thrombectomy (MT). Variables associated with QoL scores and its evolution were studied using multivariate mixed models, and interaction with time. Analyses were performed in four domains of SS-QoL: self-care, mobility, mood, and social roles. (3) Results: Among the 501 included patients (mean (sd) age 68.9 (14.5), 49% women), lower post-stroke QoL was independently related to lower level of school education, prestroke mRS > 2, and 24 h NIHSS score > 4. Independent predictors of unfavorable evolution of QoL over time were age <75 years (Mobility p = 0.0194 and Mood p = 0.0015), NIHSS score ≤ 4, (Self-care p = 0.0053 and Mood p = 0.0048), and modified Rankin Scale score ≤ 2 (Social roles, p = 0.0006). Revascularization therapy had no significant effect on the QoL scores, but patients treated with MT (alone or as bridging therapy) had significantly greater improvement in mobility score between 6 and 12 months than patients treated with IVT alone (p = 0.0072). (4) Conclusion: QoL evolution over one year had only slight variation and was associated with the modalities of acute treatment, age, and stroke severity.

Keywords: acute ischemic stroke; mechanical thrombectomy; patient reported outcomes; quality of life; revascularization therapy; thrombolysis.

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Conflict of interest statement

Yannick Béjot reports personal fees from BMS, Pfizer, Medtronic, Amgen, Servier, Boehringer-Ingelheim, and NovoNordisk outside the submitted work. Hervé Devilliers reports personal fees from GSK and Janssens, outside the submitted work. Other authors: none.

Figures

Figure 1
Figure 1
Participant selection flowchart.
Figure 2
Figure 2
Mean self-care score at 6 months and 12 months according to patients’ characteristics.
Figure 3
Figure 3
Mean mobility score at 6 months and 12 months according to patients’ characteristics. PAD, peripheral artery disease; CKD, chronic kidney disease.
Figure 4
Figure 4
Mean mood score at 6 months and 12 months according to patients’ characteristics.
Figure 5
Figure 5
Mean social roles score at 6 months and 12 months according to patients’ characteristics. CKD, chronic kidney disease.
See this image and copyright information in PMC

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