Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 May 29;12(11):1855.
doi: 10.3390/nano12111855.

Recent Advances in Antimicrobial Nano-Drug Delivery Systems

Tong-Xin Zong  1 , Ariane Pandolfo Silveira  2 , José Athayde Vasconcelos Morais  2 , Marina Carvalho Sampaio  2 , Luis Alexandre Muehlmann  2   3 , Juan Zhang  1 , Cheng-Shi Jiang  1 , Shan-Kui Liu  1
Affiliations
Review

Recent Advances in Antimicrobial Nano-Drug Delivery Systems

Tong-Xin Zong et al. Nanomaterials (Basel). .

Abstract

Infectious diseases are among the major health issues of the 21st century. The substantial use of antibiotics over the years has contributed to the dissemination of multidrug resistant bacteria. According to a recent report by the World Health Organization, antibacterial (ATB) drug resistance has been one of the biggest challenges, as well as the development of effective long-term ATBs. Since pathogens quickly adapt and evolve through several strategies, regular ATBs usually may result in temporary or noneffective treatments. Therefore, the demand for new therapies methods, such as nano-drug delivery systems (NDDS), has aroused huge interest due to its potentialities to improve the drug bioavailability and targeting efficiency, including liposomes, nanoemulsions, solid lipid nanoparticles, polymeric nanoparticles, metal nanoparticles, and others. Given the relevance of this subject, this review aims to summarize the progress of recent research in antibacterial therapeutic drugs supported by nanobiotechnological tools.

Keywords: antimicrobial; antimicrobial resistance; drug delivery systems; nanocarriers; nanoparticles.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The main resistance mechanisms of gram-negative bacteria to antibiotics.
Figure 2
Figure 2
Liposome based drug delivery. Reprinted from ref. [28]. Copyright 2022 by BioRender.
Figure 3
Figure 3
Blank polymer micelles (a) and drug-loaded polymer micelles (b).
Figure 4
Figure 4
Nanogel.
Figure 5
Figure 5
Nanoemulsion.
See this image and copyright information in PMC

References

    1. Zhen X., Li Y., Chen Y., Dong P., Liu S., Dong H. Effect of multiple drug resistance on total medical costs among patients with intra-abdominal infections in China. PLoS ONE. 2018;13:e0193977. doi: 10.1371/journal.pone.0193977. - DOI - PMC - PubMed
    1. Makabenta J.M.V., Nabawy A., Li C.H., Schmidt-Malan S., Patel R., Rotello V.M. Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections. Nat. Rev. Microbiol. 2021;19:23–36. doi: 10.1038/s41579-020-0420-1. - DOI - PMC - PubMed
    1. Kohanski M.A., Dwyer D.J., Collins J.J. How antibiotics kill bacteria: From targets to networks. Nat. Rev. Microbiol. 2010;8:423–435. doi: 10.1038/nrmicro2333. - DOI - PMC - PubMed
    1. Blair J., Webber M.A., Baylay A.J., Ogbolu D.O., Piddock L.J. Molecular mechanisms of antibiotic resistance. Nat. Rev. Microbiol. 2015;13:42–51. doi: 10.1038/nrmicro3380. - DOI - PubMed
    1. Munita J.M., Arias C.A. Mechanisms of Antibiotic Resistance. Microbiol. Spectr. 2016;4:15. doi: 10.1128/microbiolspec.VMBF-0016-2015. - DOI - PMC - PubMed

LinkOut - more resources